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The antiarrhythmic properties of β-adrenoceptor antagonists

1989; Elsevier BV; Volume: 10; Issue: 1 Linguagem: Inglês

10.1016/0165-6147(89)90104-1

1873-3735

Adriaan P. IJzerman, W. Soudijn,

Analytical Methods in Pharmaceuticals

The antiarrhythmic properties of β-adrenoceptor antagonists have long been recognized and, according to the Vaughan Williams classification of anti-arrhythmic drugs, these drugs are regarded as a separate entity, namely class II. In this review. Ad IJzerman and Willem Soudijn focus on the nature and the molecular basis of the antiarrhythmic action of β-adrenoceptor antagonists. Structure-activity relationship studies demonstrate that the antiarrhythmic profile of different β-adrenoceptor antagonists is not fixed and some compounds have class I or class III properties which may be clinically relevant.