Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
2009; Elsevier BV; Volume: 19; Issue: 6 Linguagem: Inglês
10.1016/j.bmcl.2009.02.025
ISSN1464-3405
AutoresJianchun Qin, Yamei Zhang, Jin‐Ming Gao, Ming‐Sheng Bai, Sheng‐Xiang Yang, Hartmut Laatsch, Anling Zhang,
Tópico(s)Plant biochemistry and biosynthesis
ResumoA novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1–4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.
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