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Blood Lead Concentration Is Not Altered by High‐Dose Vitamin D Supplementation in Children and Young Adults With HIV

2012; Lippincott Williams & Wilkins; Volume: 56; Issue: 3 Linguagem: Inglês

10.1097/mpg.0b013e3182758c4a

1536-4801

Véronique Groleau, Rachel A. Herold, Joan I. Schall, Julia Wagner, Kelly A. Dougherty, Babette S. Zemel, Richard M. Rutstein, Virginia A. Stallings,

Pharmacological Effects and Toxicity Studies

Optimal vitamin D status is known to have beneficial health effects and vitamin D supplements are commonly used. It has been suggested that vitamin D supplementation may increase blood lead in children and adults with previous lead exposure. The objective was to determine the safety regarding lead toxicity during 12 weeks of high-dose vitamin D3 supplementation in children and young adults with human immunodeficiency virus (HIV).Subjects with HIV (8-24 years) were randomized to vitamin D3 supplementation of 4000 or 7000 IU/day and followed at 6 and 12 weeks for changes in serum 25-hydroxy vitamin D (25D) and whole-blood lead concentration. This was a secondary analysis of a larger study of vitamin D3 supplementation in children and adolescents with HIV.In 44 subjects (75% African American), the baseline mean ± standard deviation serum 25D was 48.3±18.6 nmol/L. Fifty percent of subjects had baseline serum 25D 5.0 μg/dL at baseline or during subsequent visits. Whole-blood lead and 25D were not correlated at baseline, and were negatively correlated after 12 weeks of supplementation (P=0.014). Whole-blood lead did not differ between those receiving 4000 and 7000 IU of vitamin D3.High-dose vitamin D3 supplementation and the concomitant increased serum 25D did not result in increased whole-blood lead concentration in this sample of children and young adults living in a northeastern urban city.