Symptomless celiac disease in type 1 diabetes: 12‐year experience in Estonia
2009; Wiley; Volume: 52; Issue: 2 Linguagem: Inglês
10.1111/j.1442-200x.2009.02955.x
ISSN1442-200X
AutoresRaivo Uibo, Kaire Heilman, Tiina Rägö, Riina Shor, Mare Paal, Kaja Metsküla, Vallo Tillmann, Raivo Uibo,
Tópico(s)Microbial Metabolites in Food Biotechnology
ResumoWe aimed to determine the prevalence and characteristics of celiac disease in children with type 1 diabetes in Estonia, a country with a formerly low frequency of both diseases.Altogether, 271 patients with diabetes were studied over 12 years (1995-2006): 122 at diagnosis and 149 patients 0.1-14.8 years after diagnosis. In addition, 73 patients were followed up over 1-6 years. Immunoglobulin A type endomysium and tissue transglutaminase antibodies were determined. Patients with antibodies and/or with celiac-disease-related symptoms were invited for a small-intestinal biopsy.At the primary screening, celiac disease was histologically confirmed in nine patients (all without symptoms), that is, in 3.3% (95% confidence interval: 1.63-6.42) of type 1 diabetes cases. At follow up, celiac disease was additionally detected in two (2.7%) of 73 diabetic patients, that is, in 0.016 (95% confidence interval: 0-0.072) celiac disease cases per follow-up year.The prevalence of celiac disease among type 1 diabetes patients in Estonia is similar to that in countries with a high incidence of celiac disease and type 1 diabetes. As celiac disease is mostly symptomless, all children with type 1 diabetes, irrespective of their geographic origin, should be regularly screened for celiac disease.
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