Synthesis of arylbromides from arenes and N -bromosuccinimide (NBS) in acetonitrile — A convenient method for aromatic bromination
2009; NRC Research Press; Volume: 87; Issue: 2 Linguagem: Inglês
10.1139/v08-176
ISSN1480-3291
AutoresEli Zysman‐Colman, Karla I. Arias, Jay S. Siegel,
Tópico(s)Chemical Synthesis and Reactions
ResumoRegioselective and chemoselective electrophilic bromination of a wide series of activated arenes using N-bromosuccinimide (NBS) in acetonitrile occurs readily. Environmentally friendly conditions, large substrate scope, and ease of synthesis enhance the utility of this method over other electrophilic bromination conditions.
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