Artigo Acesso aberto Revisado por pares

Leukemoid Reaction in Association with Bone Marrow Necrosis due to Metastatic Prostate Cancer

2005; The Japanese Society of Internal Medicine; Volume: 44; Issue: 10 Linguagem: Inglês

10.2169/internalmedicine.44.1093

ISSN

1349-7235

Autores

Taichi Azuma, Ikuya Sakai, Takuya Matsumoto, Akira Ozawa, Nozomu Tanji, Akito Watanabe, Naoyuki Uchida, Hirosi Narumi, Yoshihiro Yakushijin, Takaaki Hato, Masaki Yasukawa, Shigeru Fujita,

Tópico(s)

Dermatological and COVID-19 studies

Resumo

An 80-year-old man presented to the internist with fever, fatigue and leukocytosis up to 66.8×103/μl. Although a chronic myelogenous leukemia was initially suspected, he was diagnosed as metastatic bone marrow tumor with bone marrow necrosis from primary prostate cancer on the basis of the clinical and pathological findings. The serum concentrations of IL-6 and TNF-α were mildly elevated to 65.0 pg/ml and, 54.0 pg/ml respectively. It is probable that these humoral factors were partially responsible for the leukemoid reaction although other factors induced by the bone marrow necrosis with bone marrow metastasis of prostate cancer are also likely involved.

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