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Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3–q13.5

1995; Elsevier BV; Volume: 25; Issue: 2 Linguagem: Inglês

10.1016/0888-7543(95)80063-r

1089-8646

Roberto D. Polakiewicz, David J. Munroe, S N Sait, Kazimierz T. Tycowski, Norma J. Nowak, Thomas B. Shows, David E. Housman, David C. Page,

Cancer-related molecular mechanisms research

The mammalian ribosome is a massive structure composed of 4 RNA species and about 80 different proteins. One of these ribosomal proteins, S3, appears to function not only in translation but also as an endonuclease in repair of UV-induced DNA damage. Moreover, the first intron of human RPS3 transcripts is processed to generate U15A, a small nucleolar RNA. We localized the nested RPS3/U15A genes to the immediate vicinity of D11S356 and D11S533 on human chromosome 11q13.3–q13.5 using a combination of somatic cell hybrid analysis, fluorescence in situ hybridization, and YAC/STS content mapping. These findings add to the evidence that genes encoding ribosomal proteins are scattered about the human genome.