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Comparative study of immunologic methods for demonstration of antibodies to soluble nuclear antigens

1977; Wiley; Volume: 20; Issue: 2 Linguagem: Inglês

10.1002/art.1780200209

1529-0131

Masashi Akizuki, Runas Powers, Halsted R. Holman,

Galectins and Cancer Biology

Abstract Four methods to detect antibodies reactive with soluble nuclear antigens were compared—the fluorescent antibody technique, hemagglutination, complement fixation, and immunodiffusion. Certain advantages and disadvantages of each method are described. The first three methods have greater sensitivity than immunodiffusion, but immunodiffusion discriminates most reliably between different antibodies.