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NMR spectroscopy: a powerful tool for detecting the conformational features of symmetrical persubstituted mixed cyclomaltoheptaoses (β-cyclodextrins)

2004; Elsevier BV; Volume: 340; Issue: 2 Linguagem: Inglês

10.1016/j.carres.2004.11.022

1873-426X

Gloria Uccello‐Barretta, Giuseppe Sicoli, Federica Balzano, Piero Salvadori,

Drug Solubulity and Delivery Systems

The conformation in solution of exhaustively derivatized mixed cyclomaltooligosaccharides (cyclodextrins) has been defined by NMR spectroscopy. Both tilting of glucopyranose units about the glycosidic linkages and ring deviations from the 4C1 chair conformation are detected, the entities of which are strongly dependent on the nature of the derivatizing groups.