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Two C21-steroidal glycosides isolated from Cynanchum stauntoi

1999; Elsevier BV; Volume: 52; Issue: 7 Linguagem: Inglês

10.1016/s0031-9422(99)00439-2

1873-3700

Nanqun Zhu, Mingfu Wang, Hiroe Kikuzaki, Nobuji Nakatani, Chi‐Tang Ho,

Natural product bioactivities and synthesis

Studies on the roots of Cynanchum stauntoi led to the isolation of two C21-steroidal glycosides, formally named stauntosides A and B. Their structures were elucidated on the basis of spectroscopic evidence, especially that from analysis of 2D-NMR spectra. They were found to possess an unusual skeleton and were identified as stauntogenin 3-O-alpha-L-diginopyranosyl-(1-4)-beta-L-cymaropyranosyl-(1- 4)-beta-D- digitoxopyranosyl-(1-4)-beta-D-thevetopyranoside and stauntogenin 3-O-alpha-L-cymaropyranosyl-(1-4)-beta-D-digitoxopyranosyl-( 1-4)-beta-D-3- demethyl-2-deoxy-thevetopyranoside.