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An arabinogalactan with anti-ulcer protective effects isolated from Cereus peruvianus

2010; Elsevier BV; Volume: 82; Issue: 3 Linguagem: Inglês

10.1016/j.carbpol.2010.05.043

1879-1344

Leonardo Yugo Abe Tanaka, Arildo José Braz de Oliveira, José Eduardo Gonçalves, Thales R. Cipriani, Lauro Mera de Souza, Maria Consuelo Andrade Marques, Maria Fernanda de Paula Werner, Cristiane Hatsuko Baggio, Philip A.J. Gorin, Guilherme L. Sassaki, Marcello Iacomini,

Phytochemical Studies and Bioactivities

A type I arabinogalactan (CPP) was isolated from the viscous gum exuded by Cereus peruvinus (Cactaceae). It contained arabinose, galactose, galacturonic acid, and rhamnose in a 15:66:6:13 molar ratio and had Mw 9 × 105 g mol−1. Methylation analysis and 13C NMR spectroscopy indicated that CPP is composed of a (1 → 4)-linked β-d-Galp main-chain with substituents of α-l-Araf at O-2, O-3 and O-6, which are in turn substituted at O-2, O-3, and O-2,3. These are probably linked to O-4 of some rhamnosyl units of a type I rhamnogalacturonan (RG1). The main chain is formed by repeating (1 → 4)-α-d-GalpA-(1 → 2)-α-l-Rhap groups. The methylation analysis suggested the presence of (1 → 3)-linked β-Galp structures, perhaps linked to the (1 → 4)-linked β-d-Galp backbone. CPP significantly inhibited ethanol-induced gastric lesions in rats at an ED50 of 49 mg kg−1, indicating that it has a gastroprotective effect. The gastric lesion inhibition by CPP suggests a potential use of this polysaccharide, or the crude plant extract, in phytotherapy.