Portal de Periódicos da CAPES

A Clinical Study Comparing the Skin Antisepsis and Safety of ChloraPrep, 70% Isopropyl Alcohol, and 2% Aqueous Chlorhexidine

2002; Lippincott Williams & Wilkins; Volume: 25; Issue: 4 Linguagem: Inglês

10.1097/00129804-200207000-00007

1539-0667

John S. Hibbard, Gayle Mulberry, Ann R. Brady,

Surgical site infection prevention

ChloraPrep (2% chlorhexidine gluconate + 70% isopropyl alcohol [CHG + IPA] in a 3.0-mL applicator) is a recently approved antiseptic for preoperative skin preparation. This controlled open-label trial assessed the immediate and persistent antimicrobial efficacy and safety of CHG + IPA compared with 70% IPA or a 2% CHG aqueous solution alone. Each antiseptic significantly reduced abdominal and inguinal microbial counts from baseline at 10 minutes, 6 hours, and 24 hours ( P =.0001). CHG + IPA provided significantly more persistent antimicrobial activity on abdominal sites than IPA ( P =.003) or CHG ( P =.028) at 24 hours. No skin irritations were reported for any of the three antiseptics.