Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

2011; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 5 Linguagem: Inglês

10.3390/ijms12053352

1661-6596

Kaline Dantas Magalhães, Leandro Silva Costa, Gabriel Pereira Fidelis, Ruth Medeiros Oliveira, Leonardo Thiago Duarte Barreto Nobre, Nednaldo Dantas-Santos, Rafael Barros Gomes Câmara, Ivan Rui Lopes Albuquerque, Sara Lima Cordeiro, Diego Araújo Sabry, Mariana Santana Santos Pereira Costa, Luciana G. Alves, Hugo Alexandre Oliveira Rocha,

Echinoderm biology and ecology

In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (∼45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.