Portal de Periódicos da CAPES

The Effect of Lymphatic Tumor Burden on Sentinel Lymph Node Biopsy Results

2002; Wiley; Volume: 8; Issue: 4 Linguagem: Inglês

10.1046/j.1524-4741.2002.08402.x

1524-4741

Sandra L. Wong, Michael J. Edwards, Celia Chao, Diana Simpson, Kelly M. McMasters,

Breast Implant and Reconstruction

The Breast JournalVolume 8, Issue 4 p. 192-198 The Effect of Lymphatic Tumor Burden on Sentinel Lymph Node Biopsy Results Sandra L. Wong MD, Sandra L. Wong MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorMichael J. Edwards MD, Michael J. Edwards MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorCelia Chao MD, Celia Chao MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorDiana Simpson RN, Diana Simpson RN Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorKelly M. McMasters MD, PhD, Corresponding Author Kelly M. McMasters MD, PhD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, Kentucky for the University of Louisville Breast Cancer Study GroupAddress correspondence and reprint requests to: Kelly M. McMasters, MD, PhD, University of Louisville, J. Graham Brown Cancer Center, 529 S. Jackson St., #318, Louisville, KY 40202, or e-mail: kelly.mcmasters@nortonhealthcare.orgSearch for more papers by this author Sandra L. Wong MD, Sandra L. Wong MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorMichael J. Edwards MD, Michael J. Edwards MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorCelia Chao MD, Celia Chao MD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorDiana Simpson RN, Diana Simpson RN Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KentuckySearch for more papers by this authorKelly M. McMasters MD, PhD, Corresponding Author Kelly M. McMasters MD, PhD Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, Kentucky for the University of Louisville Breast Cancer Study GroupAddress correspondence and reprint requests to: Kelly M. McMasters, MD, PhD, University of Louisville, J. Graham Brown Cancer Center, 529 S. Jackson St., #318, Louisville, KY 40202, or e-mail: kelly.mcmasters@nortonhealthcare.orgSearch for more papers by this author First published: 13 August 2002 https://doi.org/10.1046/j.1524-4741.2002.08402.xCitations: 30 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Increasing tumor burden in the axilla, as determined by the number of positive lymph nodes, adversely affects sentinel lymph node (SLN) identification and false-negative rates. The University of Louisville Breast Cancer Sentinel Lymph Node Study is a prospective, multi-institutional study. All enrolled patients underwent SLN biopsy, followed by complete level I/II axillary dissection. Participating surgeons represent a variety of practice settings, mostly community-based private practice. A total of 229 surgeons enrolled 2206 patients between August 1997 and November 2000. SLN biopsy was performed using blue dye injection alone, radioactive colloid alone, or a combination of the two agents. Two key parameters used to measure SLN biopsy success are the SLN identification rate and SLN false-negative rate. The overall SLN identification and false-negative rates were 92.5% and 8.0%, respectively. With increasing numbers of positive axillary nodes, there was a decreased sentinel node identification rate. There was no difference in the false-negative rate with increasing axillary tumor burden. Increased tumor burden in the axilla (as determined by the mean number of positive nodes) is associated with failure to identify a SLN in some cases, but is not an explanation for false-negative results. Standard axillary dissection should be performed when a SLN cannot be identified. Citing Literature Volume8, Issue4July 2002Pages 192-198 RelatedInformation