2,6-di-tert-butyl-4- methylene-2,5-cyclohexadienone: A hepatic metabolite of butylated hydroxytoluene in rats
1979; Elsevier BV; Volume: 17; Issue: 5 Linguagem: Inglês
10.1016/0015-6264(79)90003-8
ISSN1878-6049
Autores Tópico(s)Cancer Treatment and Pharmacology
ResumoTwo metabolites of butylated hydroxytoluene were isolated from the livers of orally treated male rats. The major metabolite was identified as 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone, by gas chromatography and mass spectroscopy and by reduction with lithium aluminium hydride. Only non-conjugated unchanged BHT was identified in samples of lung, kidney, pancreas, brain and adipose tissue from these rats.
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