Genetic susceptibility to aminoglycoside ototoxicity: How many are at risk?
2002; Elsevier BV; Volume: 4; Issue: 5 Linguagem: Inglês
10.1097/00125817-200209000-00004
ISSN1530-0366
AutoresHsiao‐Yuan Tang, Eldridge Hutcheson, Susan U. Neill, Margaret Drummond‐Borg, Michael E. Speer, Raye Lynn Alford,
Tópico(s)Vestibular and auditory disorders
ResumoPurpose: To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity.Methods: Genetic analysis of anonymized, residual diagnostic specimens.Results: One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956–960insC, were also found in six and five specimens, respectively.Conclusions: Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
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