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Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR-dependent repression mechanism

2003; Wiley; Volume: 536; Issue: 1-3 Linguagem: Inglês

10.1016/s0014-5793(03)00028-0

1873-3468

Mark Wasner, Katrin Tschöp, Katja Spiesbach, Ulrike Haugwitz, C Johne, Joachim Mössner, Roberto Mantovani, Kurt Engeland,

Ubiquitin and proteasome pathways

Cyclin B is a central regulator of transition from the G 2 phase of the cell cycle to mitosis. In mammalian cells two B‐type cyclins have been characterised, cyclin B1 and B2. Both are expressed with a maximum in G 2 and their synthesis is mainly regulated on the transcriptional level. We show that a single cell cycle genes homology region, lacking a functional cell cycle‐dependent element in tandem with it, contributes most of the cell cycle‐dependent transcription from the cyclin B1 promoter. The coactivator p300 binds to the cyclin B1 promoter and synergises with the transcription factor NF‐Y in activating transcription of cyclin B1 .