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Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis

1973; Elsevier BV; Volume: 304; Issue: 3 Linguagem: Inglês

10.1016/0304-4165(73)90217-1

1872-8006

Přemysl Poňka, J Borová, J Neuwirt,

Hemoglobin structure and function

Incubation of rabbit reticulocytes with cycloheximide and 59Fe bound to transferrin in plasma induces excessive non-hemoglobin 59Fe-labeled heme accumulation in mitochondria. During incubation of these mitochondria in vitro a part of 59Fe-labeled heme is released into the surrounding medium. The addition of globin or bovine serum albumin to the incubation mixture essentially increases the amount of heme released from mitochondria.