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MULTICENTRIC RETICULOHISTIOCYTOSIS IN A PATIENT WITH MALIGNANT MELANOMA: A RESPONSE TO CYCLOPHOSPHAMIDE AND A UNIQUE CUTANEOUS FEATURE

1990; Wiley; Volume: 33; Issue: 7 Linguagem: Inglês

10.1002/art.1780330720

1529-0131

Jay G. Kenik, Christopher Huerter, John A. Hurley, James F. Stanosheck,

Mast cells and histamine

Abstract We describe a patient with multicentric reticulohistiocytosis and a history of malignant melanoma. His widely disseminated disease did not affect the site of surgical removal of the malignant melanoma nor the donor site of a skin graft. The multicentric reticulohistiocytosis progressed while the patient was taking nonsteroidal antiinflammatory agents, but showed significant response during a 10‐month course of cyclophosphamide. While he was taking the cyclophosphamide, however, his melanoma recurred, and the patient subsequently died.