Portal de Periódicos da CAPES

(BDP)CuH: A “Hot” Stryker's Reagent for Use in Achiral Conjugate Reductions

2007; American Chemical Society; Volume: 10; Issue: 2 Linguagem: Inglês

10.1021/ol702689v

1523-7060

Benjamin Baker, Žarko Bošković, Bruce H. Lipshutz,

Synthetic Organic Chemistry Methods

A ligand-modified, economical version of Stryker's reagent (SR) has been developed based on a bidentate, achiral bis-phosphine. Generated in situ, "(BDP)CuH" smoothly effects conjugate reductions of a variety of unsaturated substrates, including those that are normally unreactive toward SR. Substrate-to-ligand ratios typically on the order of 1000-10000:1 can be used leading to products in high yields.