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Visualizing the First 50 Hr of the Primary Immune Response to a Soluble Antigen

2004; Cell Press; Volume: 21; Issue: 3 Linguagem: Inglês

10.1016/j.immuni.2004.08.007

1097-4180

Drew M. Catron, Andrea Itano, Kathryn A. Pape, Daniel L. Mueller, Marc K. Jenkins,

Immune Cell Function and Interaction

Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.