Dengue viral infections; pathogenesisand epidemiology
2000; Elsevier BV; Volume: 2; Issue: 9 Linguagem: Inglês
10.1016/s1286-4579(00)01258-2
ISSN1769-714X
AutoresWilliam J. McBride, Helle Bielefeldt‐Ohmann,
Tópico(s)Viral Infections and Outbreaks Research
ResumoDengue viral infections affect up to 100 million individuals per year. Dengue haemorrhagic fever is a clinical form of disease characterised by intravascular fluid loss. There has been a marked increase in the incidence of this form of the disease over the last few decades, associated with significant mortality, particularly in the paediatric population. A number of theories relating to the pathogenesis of dengue haemorrhagic fever exist that have evolved from the analysis of the epidemiology of this disease. Virological and immunopathological factors are both important but the exact mechanisms for the disease are unknown.
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