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Modulation byDLST of the genetic risk of Alzheimer's disease in a very elderly population

1999; Wiley; Volume: 45; Issue: 1 Linguagem: Inglês

10.1002/1531-8249(199901)45

1531-8249

Kwan‐Fu Rex Sheu, Abraham M. Brown, Vahram Haroutunian, Bruce S. Kristal, Howard T. Thaler, Martin Lesser, Rajesh N. Kalaria, Norman Relkin, Richard C. Mohs, Lena Lilius, Lars Lannfelt, John P. Blass,

Folate and B Vitamins Research

Annals of NeurologyVolume 45, Issue 1 p. 48-53 Original Article Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population Kwan-Fu Rex Sheu PhD, Corresponding Author Kwan-Fu Rex Sheu PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYBurke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605Search for more papers by this authorAbraham M. Brown PhD, Abraham M. Brown PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this authorVahram Haroutunian PhD, Vahram Haroutunian PhD Bronx VA Medical Center and Mount Sinai School of Medicine, Manhasset, NYSearch for more papers by this authorBruce S. Kristal PhD, Bruce S. Kristal PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this authorHoward Thaler PhD, Howard Thaler PhD Sloan-Kettering Medical Research Center, Manhasset, NYSearch for more papers by this authorMartin Lesser PhD, Martin Lesser PhD North Shore University Hospital, New York University School of Medicine, Manhasset, NYSearch for more papers by this authorRajesh N. Kalaria MD, PhD, Rajesh N. Kalaria MD, PhD Case Western Reserve University Medical School, Cleveland, OHSearch for more papers by this authorNorman R. Relkin MD, Norman R. Relkin MD Cornell University Medical College, Manhasset, NYSearch for more papers by this authorRichard C. Mohs PhD, Richard C. Mohs PhD Bronx VA Medical Center and Mount Sinai School of Medicine, Manhasset, NYSearch for more papers by this authorLena Lilius Bsc, Lena Lilius Bsc Karolinska Institute, Huddinge University Hospital, Stockholm, SwedenSearch for more papers by this authorLars Lannfelt MD, PhD, Lars Lannfelt MD, PhD Karolinska Institute, Huddinge University Hospital, Stockholm, SwedenSearch for more papers by this authorJohn P. Blass MD, PhD, John P. Blass MD, PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this author Kwan-Fu Rex Sheu PhD, Corresponding Author Kwan-Fu Rex Sheu PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYBurke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605Search for more papers by this authorAbraham M. Brown PhD, Abraham M. Brown PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this authorVahram Haroutunian PhD, Vahram Haroutunian PhD Bronx VA Medical Center and Mount Sinai School of Medicine, Manhasset, NYSearch for more papers by this authorBruce S. Kristal PhD, Bruce S. Kristal PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this authorHoward Thaler PhD, Howard Thaler PhD Sloan-Kettering Medical Research Center, Manhasset, NYSearch for more papers by this authorMartin Lesser PhD, Martin Lesser PhD North Shore University Hospital, New York University School of Medicine, Manhasset, NYSearch for more papers by this authorRajesh N. Kalaria MD, PhD, Rajesh N. Kalaria MD, PhD Case Western Reserve University Medical School, Cleveland, OHSearch for more papers by this authorNorman R. Relkin MD, Norman R. Relkin MD Cornell University Medical College, Manhasset, NYSearch for more papers by this authorRichard C. Mohs PhD, Richard C. Mohs PhD Bronx VA Medical Center and Mount Sinai School of Medicine, Manhasset, NYSearch for more papers by this authorLena Lilius Bsc, Lena Lilius Bsc Karolinska Institute, Huddinge University Hospital, Stockholm, SwedenSearch for more papers by this authorLars Lannfelt MD, PhD, Lars Lannfelt MD, PhD Karolinska Institute, Huddinge University Hospital, Stockholm, SwedenSearch for more papers by this authorJohn P. Blass MD, PhD, John P. Blass MD, PhD Burke Medical Research Institute, White Plains, NY Cornell University Medical College, Manhasset, NYSearch for more papers by this author First published: 31 May 2001 https://doi.org/10.1002/1531-8249(199901)45:1 3.0.CO;2-VCitations: 25AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC) is deficient in Alzheimer's disease (AD). The DLST gene encodes the core, dihydrolipoyl succinyltransferase (DLST) component of KGDHC, and recent reports indicate an association between polymorphisms of DLST and AD in both white and Japanese patients. We therefore examined the relationship between AD and the DLST and apolipoprotein E (APOE) genes in elderly (89 ± 7 years) AD patients, in whom the ε4 allele of APOE (APOE4) is a weak risk factor for AD. Polymorphisms of DLST (A19,117G and T19,183C), shown to be of interest in previous studies, were analyzed by restriction fragment length polymorphism analysis after polymerase chain reaction amplification. In a series of 429 white subjects from two Jewish nursing homes, an association of APOE4 with AD was found only in patients homozygous for the G,C allele of DLST. Similar relationships occurred in the "very elderly" (≥85 years, n = 302) subgroup of this series, and also in an autopsy series (n = 225) that included white subjects from the Jewish nursing homes as well as other white subjects. These findings suggest a relationship between APOE4 and a DLST locus in the pathogenesis of AD in very elderly subjects. Ann Neurol 1999;45:48–53 Citing Literature Volume45, Issue1January 1999Pages 48-53 RelatedInformation