Portal de Periódicos da CAPES

Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth

2014; Lippincott Williams & Wilkins; Volume: 83; Issue: 23 Linguagem: Inglês

10.1212/wnl.0000000000001045

1526-632X

Bérengère Aubert-Broche, Vladimir Fonov, Sridar Narayanan, Douglas L. Arnold, David Araújo, Dumitru Fetco, Christine Till, John G. Sled, Brenda Banwell, D. Louis Collins, Mark Awuku, Louise Roberts, Janis Baird, Nancy Cacciotti, Brenda Banwell, Amy Waldman, Ann Ming Yeh, Danielle Boyce, Kimberly Carn-Louise, Stephanie A. Grover, Julia O’Mahony, Carmen Yea, Melissa McGowan, Emily Ursell, Sandra Magalhaes, Courtney Fairbrother, Julia Kennedy, Jennifer D. Hamilton, Samantha Irwin, Amit Bar‐Or, Rozie Arnaoutelis, Virender Bhan, Trudy L. Campbell, Lucy Sagar, Kelly Sabourin, Fran Booth, Ruth Ann Marrie, Shirley Fredrickson, D. A. H. Buckley, Dianne McGrath, Sharon Penney, Mary Connolly, Shiela Richards, Shelia Kent, Vesna Popovska, Pamela Cooper, Loris Aro, Marie-Emmanuelle Dilenge, Geneviève Bernard, Heather Davies, Pat Terrone, Asif Doja, Daniela Pohl, Sunita Venkateswaran, Sharon Whiting, Chantal Horth, Sheila Ledoux, François Grand’Maison, Julie Lafrenière, Simon Levin, Vinolia Arthur‐Hayward, Mala Ramu, Anne Lortie, S. Morin, Fabiola Breault, Stéphanie Pellerin, Eilidh A. MacDonald, Vee McBride, Jean K. Mah, Jordan Turley, Caitlin Wright, Natarie Liu, Catherine Riddell, Brandon Meaney, Dave Callen, L. Morgenstern, Laurie Wyllie, Heather B. Neuman, David Meek, Alison Crowell, Noel Lowry, Doris Newmeyer, Guillaume Sébire, Anik Giguère, C. Houde, Anthony Traboulsee, Mário L de Lemos, Kati Wambera, Colleen Adams, Laurie Robson, Ellen Wood, Elaine Woolridge, Edythe Smith, Jerome Y. Yager, Marjorie Berg, Hope Chick, Conrad Yim, Louise Bentley, Lysander Montgomery,

Multiple Sclerosis Research Studies

Objective: To determine the impact of pediatric-onset multiple sclerosis (MS) on age-expected brain growth. Methods: Whole brain and regional volumes of 36 patients with relapsing-remitting MS onset prior to 18 years of age were segmented in 185 longitudinal MRI scans (2–11 scans per participant, 3-month to 2-year scan intervals). MRI scans of 25 age- and sex-matched healthy normal controls (NC) were also acquired at baseline and 2 years later on the same scanner as the MS group. A total of 874 scans from 339 participants from the NIH-funded MRI study of normal brain development acquired at 2-year intervals were used as an age-expected healthy growth reference. All data were analyzed with an automatic image processing pipeline to estimate the volume of brain and brain substructures. Mixed-effect models were built using age, sex, and group as fixed effects. Results: Significant group and age interactions were found with the adjusted models fitting brain volumes and normalized thalamus volumes ( p < 10 −4 ). These findings indicate a failure of age-normative brain growth for the MS group, and an even greater failure of thalamic growth. In patients with MS, T2 lesion volume correlated with a greater reduction in age-expected thalamic volume. To exclude any scanner-related influence on our data, we confirmed no significant interaction of group in the adjusted models between the NC and NIH MRI Study of Normal Brain Development groups. Conclusions: Our results provide evidence that the onset of MS during childhood and adolescence limits age-expected primary brain growth and leads to subsequent brain atrophy, implicating an early onset of the neurodegenerative aspect of MS.