7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors
2005; Pharmaceutical Society of Japan; Volume: 28; Issue: 9 Linguagem: Inglês
10.1248/bpb.28.1798
ISSN1347-5215
AutoresSachiko Tsukamoto, Takeshi Wakana, Keiichirou Koimaru, Takushi Yoshida, Mako Sato, Tomihisa Ohta,
Tópico(s)Natural product bioactivities and synthesis
ResumoThe extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4′-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1—3 induced neurite outgrowth in PC-12 cells at concentration of 50 μg/ml, while 4 was less active. In addition, compounds 2—4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
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