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High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-( S )-pyrrolidine

2003; Wiley; Volume: 59; Issue: 7 Linguagem: Inglês

10.1107/s0907444903010059

1399-0047

Christian Oefner, A. D’Arcy, A. Mac Sweeney, Sabine Pierau, Rana Gardiner, Glenn E. Dale,

Diabetes Treatment and Management

Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.