Current trends in essential thrombocythaemia
2002; Wiley; Volume: 117; Issue: 4 Linguagem: Inglês
10.1046/j.1365-2141.2002.03474.x
ISSN1365-2141
Autores Tópico(s)Chronic Myeloid Leukemia Treatments
ResumoBritish Journal of HaematologyVolume 117, Issue 4 p. 796-808 Current trends in essential thrombocythaemia Claire N. Harrison , Claire N. Harrison Department of Haematology, St Thomas' Hospital, London, UKSearch for more papers by this author Claire N. Harrison , Claire N. Harrison Department of Haematology, St Thomas' Hospital, London, UKSearch for more papers by this author First published: 10 June 2002 https://doi.org/10.1046/j.1365-2141.2002.03474.xCitations: 40 Dr Claire N. Harrison, Department of Haematology, Guy's and St Thomas' Hospital NHS Trust, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Allen, A.J.R., Gale, R.E., Harrison, C.N., Machin, S.J. & Linch. D.C. (2000) Lack of pathogenic mutations in the 5′UTR of the thrombopoietin gene in patients with non-familial essential thrombocythaemia. Blood, 96, 742a, 3209 (Abstract). Web of Science®Google Scholar Anagrelide Study Group (1992) Anagrelide, a therapy for thrombocythaemic states: experience in 577 patients. American Journal of Medicine, 92, 69 – 76. 10.1016/0002-9343(92)90017-6 PubMedWeb of Science®Google Scholar Andersson, P., Ridell, B., Wadenvik, H. & Kutti, J. (2000) Leukemic transformation of essential thrombocythaemia without previous cytoreductive treatment. Annals of Hematology, 79, 40 – 42. 10.1007/s002770050007 CASPubMedWeb of Science®Google Scholar Annaloro, C., Lambertenghi Deliliers, G., Oriani, A., Pozzoli, E., Lambertenghi Deliliers, D., Radaelli, F. & Faccini, P. (1999) Prognostic significance of bone marrow biopsy in essential thrombocythemia. Haematologica, 84, 17 – 21. CASPubMedWeb of Science®Google Scholar Axelrad, A.A., Eskinazi, D., Correa, P. & Amato, D. (2000) Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor in essential thrombocythaemia. Blood, 96, 3310 – 3321. CASPubMedWeb of Science®Google Scholar Bangerter, M., Guthner, C., Beneke, H., Hildebrand, A., Grunewald, M. & Griesshammer, M. (2000) Pregnancy in essential thrombocythaemia: treatment and outcome of 17 pregnancies. European Journal of Haematology, 65, 165 – 169. 10.1034/j.1600-0609.2000.90214.x CASPubMedWeb of Science®Google Scholar Bazzan, M., Tamponi, G., Schinco, P., Vaccarino, A., Foli, C., Gallone, G. & Pileri, A. (1999) Thrombosis-free survival and life expectancy in 187 consecutive patients with essential thrombocythemia. Annals of Hematology, 78, 539 – 543. 10.1007/s002770050555 CASPubMedWeb of Science®Google Scholar Beard, J., Hillmen, P., Anderson, C.C., Lewis, S.M. & Pearson, T.C. (1991) Primary thrombocythaemia in pregnancy. British Journal of Haematology, 77, 371 – 374 (Review). 10.1111/j.1365-2141.1991.tb08586.x CASPubMedWeb of Science®Google Scholar Bellucci, S., Janvier, M., Tobelem. G., Flandrin, G., Charpak, Y., Berger, R. & Boiron, M. (1986) Essential thrombocythemias. Clinical evolutionary and biological data. Cancer, 58, 2440 – 2447. 10.1002/1097-0142(19861201)58:11 3.0.CO;2-Y PubMedWeb of Science®Google Scholar Beressi, A.H., Tefferi, A., Silverstein, M.N., Petitt, R.M. & Hoagland, H.C. (1995) Outcome analysis of 34 pregnancies in women with essential thrombocythemia. Archives of Internal Medicine, 155, 1217 – 1222. 10.1001/archinte.155.11.1217 PubMedWeb of Science®Google Scholar Besses, C., Cervates, F., Pereira, A., Florensa, L., Sole, F., Hernandez-Boluda, J.C., Woessner, S., Sans-Sabrafen, J., Rozman, C. & Motserrat, E. (1999) Major vascular complications in essential thrombocythaemia: a study of the predictive factors in a series of 148 patients. Leukemia, 13, 150 – 154. 10.1038/sj.leu.2401270 CASPubMedWeb of Science®Google Scholar Budde, U., Schaefer, G., Mueller, N., Egli, H., Dent, J., Ruggeri, Z. & Zimmerman, T. (1984) Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood, 64, 981 – 985. 10.1182/blood.V64.5.981.981 CASPubMedWeb of Science®Google Scholar Cerutti, A., Custodi, P., Duranti, M., Noris, P. & Balduini, C.L. (1997) Thrombopoietin levels in patients with primary and reactive thrombocytosis. British Journal of Haematology, 99, 281 – 284. 10.1046/j.1365-2141.1997.3823196.x CASPubMedWeb of Science®Google Scholar Champion, K.M., Gilbert, J.G., Asimakopoulos, F.A., Hinshelwood, S. & Green, A.R. (1997) Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes. British Journal of Haematology, 97, 920 – 926. 10.1046/j.1365-2141.1997.1933010.x CASPubMedWeb of Science®Google Scholar Chiusolo, P., La Barbera, E.O., Laurenti, L., Piccirillo, N., Sora, F., Giordano, G., Urbano, R., Mazzucconi, M.G., De Stefano, V., Leone, G. & Sica, S. (2001) Clonal hemopoiesis and risk of thrombosis in young female patients with essential thrombocythemia. Experimental Hematology, 29, 670 – 676. 10.1016/S0301-472X(01)00640-3 CASPubMedWeb of Science®Google Scholar Chow, E.Y., Haley, L.P. & Vickars, L.M. (1992) Essential thrombocythemia in pregnancy: platelet count and pregnancy outcome. American Journal of Hematology, 41, 249 – 251. 10.1002/ajh.2830410405 CASPubMedWeb of Science®Google Scholar Cincotta, R., Higgins, J.R., Tippett, C., Gallery, E., North, R., McMahon, L.P. & Brennecke, S.P. (2000) Management of essential thrombocythaemia during pregnancy. Australian and New Zealand Journal of Obstetrics and Gynaecology, 40, 33 – 37. 10.1111/j.1479-828X.2000.tb03163.x CASPubMedWeb of Science®Google Scholar Cortelazzo, S., Viero, P., Finazzi, G., D'Emilio, A., Rodeghiero, F. & Barbui, T. (1990) Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. Journal of Clinical Oncology, 8, 556 – 562. 10.1200/JCO.1990.8.3.556 CASPubMedWeb of Science®Google Scholar Cortelazzo, S., Finazzi, G., Ruggeri, M., Vestri, O., Galli, M., Rodeghiero, F. & Barbui, T. (1995) Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. New England Journal of Medicine, 332, 1132 – 1136.DOI: 10.1056/NEJM199504273321704 10.1056/NEJM199504273321704 PubMedWeb of Science®Google Scholar Davis, S.C., Beuzard, Y., Borgna-Pignatti, C., Cappellini, M.-D., Ferster, A., De Franceschi, L., Fondu, P., Galacteros, F., Galanello, R., Girot, R., Roberts-Harewood, M., Loukopoulos, D., De Montalambert, M., Rachmilewitz, E. & Voskaridou, E. (1999) The effect of hydroxyurea in sickle cell disease: a European registry of benefits and toxicity. Haematology, 84, PO – 0980 (Abstract). Google Scholar Debili, N., Le Couedic, J.P., Temisien, C., Picard, F., Wendling, F., Vainchenker, W. & Casadevall, N. (1996) Autonomous growth of megakaryocyte progenitors in essential thrombocythaemia is not due to a mutation of c-Mpl. Blood, 88, 98a (Abstract). Google Scholar Delage, R., Demers, C., Cati, G. & Roy, J. (1996) Treatment of essential thrombocythaemia during pregnancy with interferon alpha. Obstetrics and Gynecology, 87, 814 – 817. PubMedWeb of Science®Google Scholar El-Kassar, N., Hetet, G., Briere, J. & Grandchamp, B. (1997) Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T lymphocytes and platelets. Blood, 89, 128 – 134. 10.1182/blood.V89.1.128 CASPubMedWeb of Science®Google Scholar Elliott, M.A. & Tefferi, A. (1997) Interferon-alpha therapy in polycythemia vera and essential thrombocythemia. Seminars in Thrombosis and Hemostasis, 23, 463 – 472 (Review). 10.1055/s-2007-996123 CASPubMedWeb of Science®Google Scholar Emmons, R.V., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E. & Shulman, N.R. (1996) Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood, 87, 4068 – 4071. 10.1182/blood.V87.10.4068.bloodjournal87104068 CASPubMedWeb of Science®Google Scholar Epstein, E. & Goedel, A. (1934) Haemorrhagische thrombocythamie bei vascularer schrumpfmilz. Virchow's Archiv Abteilung, 293, 233 – 247. 10.1007/BF01891529 Google Scholar Falconer, J., Pineo, G., Blahey, W., Bowen, T., Docksteader, B. & Jadusingh, I. (1987) Essential thrombocythemia associated with recurrent abortions and fetal growth retardation. American Journal of Hematology, 25, 345 – 347. 10.1002/ajh.2830250316 PubMedWeb of Science®Google Scholar Faurschou, M., Nielsen, O.J., Jensen, M.K. & Hasselbalch, H.C. (2000) High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders. American Journal of Hematology, 65, 136 – 140. 10.1002/1096-8652(200010)65:2 3.0.CO;2-6 CASPubMedWeb of Science®Google Scholar Fialkow, P.J., Faguet, G.B., Jacobson, R.J., Vaidya, K. & Murphy, S. (1981) Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood, 58, 916 – 919. PubMedWeb of Science®Google Scholar Finazzi, G., Budde, U. & Michiels, J.J. (1996) Bleeding time and platelet function in essential thrombocythemia and other myeloproliferative syndromes. Leukemia and Lymphoma, 22, 71 – 78. 10.3109/10428199609074363 PubMedGoogle Scholar Finazzi, G., Ruggeri, M., Rodeghiero, F. & Barbui, T. (2000) Second malignancies in patients with essential thrombocythaemia treated with busulphan and hydroxyurea: long term follow-up of a randomized clinical trial. British Journal of Haematology, 110, 577 – 583. 10.1046/j.1365-2141.2000.02188.x CASPubMedWeb of Science®Google Scholar De Gabrielle, G. & Pennington, D.G. (1967) Regulation of platelet production: 'Thrombopoietin'. British Journal of Haematology, 13, 210 – 215. 10.1111/j.1365-2141.1967.tb08733.x PubMedWeb of Science®Google Scholar Gaidano, G., Pastore, C., Santini, V., Nomdedeu, J., Gamberi, B., Capello, D., Vischia, F., Resegotti, L., Mazza, U., Ferrini, P.R., Lo Coco, F. & Saglio, G. (1997) Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia. Genes, Chromosomes and Cancer, 19, 250 – 255. 10.1002/(SICI)1098-2264(199708)19:4 3.0.CO;2-W CASPubMedWeb of Science®Google Scholar Gale, R.E. & Linch, D.C. (1994) Interpretation of X-chromosome inactivation patterns [letter; comment]. Blood, 84, 2376 – 2378. CASPubMedWeb of Science®Google Scholar Gale, R.E., Wheadon, H., Boulos, P. & Linch, D.C. (1994) Tissue specificity of X-chromosome inactivation patterns. Blood, 83, 2899 – 2905. 10.1182/blood.V83.10.2899.2899 CASPubMedWeb of Science®Google Scholar Gale, R.E., Fielding, A.K., Harrison, C.N. & Linch, D.C. (1997) Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. British Journal of Haematology, 98, 512 – 519. 10.1046/j.1365-2141.1997.2573078.x CASPubMedWeb of Science®Google Scholar Van Genderen, P.J., Michiels, J.J., Van Strik, R., Lindemans, J. & Van Vliet, H.H. (1995) Platelet consumption in thrombocythemia complicated by erythromelalgia: reversal by aspirin. Thrombosis and Haemostasis, 73, 210 – 214. CASPubMedWeb of Science®Google Scholar Van Genderen, P.J., Mulder, P.G., Waleboer, M., Van De Moesdijk, D. & Michiels, J.J. (1997) Prevention and treatment of thrombotic complications in essential thrombocythaemia: efficacy and safety of aspirin. British Journal of Haematology, 97, 179 – 184. 10.1046/j.1365-2141.1997.d01-2127.x CASPubMedWeb of Science®Google Scholar Gewirtz, A.M., Zhang, J., Ratajczak, J., Ratajczak, M., Park, K.S., Li, C., Yan, Z. & Poncz, M. (1995) Chemokine regulation of human megakaryocytopoiesis. Blood, 86, 2559 – 2567. 10.1182/blood.V86.7.2559.2559 CASPubMedWeb of Science®Google Scholar Ghilardi, N., Wiestner, A., Kikuchi, M., Oshaka, A. & Skoda, R.C. (1999) Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene. British Journal of Haematology, 107, 310 – 316. 10.1046/j.1365-2141.1999.01710.x CASPubMedWeb of Science®Google Scholar Gisslinger, H., Chott, A., Scheithauer, W., Gilly, B., Linkesch, W. & Ludwig, H. (1991) Interferon in essential thrombocythaemia. British Journal of Haematology, 79, 42 – 47. 10.1111/j.1365-2141.1991.tb08118.x PubMedWeb of Science®Google Scholar Gisslinger, H., Rodeghiero, F., Ruggeri, M., Heis-Vahidi Fard, N., Mannhalter, C., Papagiannopoulos, M., Rintele, C., Lalouschek, W., Knobl, P., Lechner, K. & Pabinger, I. (1999) Homocysteine levels in polycythaemia vera and essential thrombocythaemia. British Journal of Haematology, 105, 551 – 555. 10.1111/j.1365-2141.1999.01340.x CASPubMedWeb of Science®Google Scholar Griesshammer, M., Heimpel, H. & Pearson, T.C. (1996) Essential thrombocythaemia and pregnancy. Leukemia and Lymphoma, 22, 57 – 63. 10.3109/10428199609074361 PubMedWeb of Science®Google Scholar Griesshammer, M., Bangerter, M., Van Vliet, H.H.D.M. & Michiels, J.J. (1997) Aspirin in essential thrombocythaemia: Status Quo and Quo Vadis. Seminars in Thrombosis and Hemostasis, 23, 371 – 377. 10.1055/s-2007-996111 CASPubMedWeb of Science®Google Scholar Groopman, J.E. (1980) The pathogenesis of myelofibrosis in myeloproliferative disorders [editorial]. Annals of Internal Medicine, 92, 857 – 858. 10.7326/0003-4819-92-6-857 PubMedWeb of Science®Google Scholar Groupe Français de Cytogenetique Hematologique (1998) Cytogenetics of acutely transformed chronic myeloproliferative syndromes without a Philadelphia chromosome. A multicentric study of 55 patients. Cancer Genetics and Cytogenetics, 32, 157 – 168. Google Scholar Gunz, F.W. (1960) Haemorrhagic thrombocythaemia. a critical review. Blood, 15, 706 – 723. 10.1182/blood.V15.5.706.706 CASPubMedWeb of Science®Google Scholar Han, Z.C., Bellucci, S., Tenza, D. & Caen, J.P. (1990) Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients with essential thrombocythaemia and immune thrombocytopenic purpura. British Journal of Haematology, 74, 395 – 401. 10.1111/j.1365-2141.1990.tb06325.x PubMedWeb of Science®Google Scholar Hanft, V.N., Fruchtman, S.R., Pickens, C.V., Rosse, W.F., Howard, T.A. & Ware, R.E. (2000) Acquired DNA mutations associated with in vivo hydroxyurea exposure. Blood, 95, 3589 – 3593. 10.1182/blood.V95.11.3589 CASPubMedWeb of Science®Google Scholar Harrison, C.N. & Machin, S.J. (1997) Essential thrombocythaemia and antiphospholipid antibodies. American Journal of Medicine, 102, 317 – 318. PubMedWeb of Science®Google Scholar Harrison, C.N., Gale, R.E., Wiestner, A.C., Skoda, R.C. & Linch, D.C. (1998a) The activating splice mutation in intron 3 of the thrombopoietin gene is not found in patients with non-familial essential thrombocythaemia. British Journal of Haematology, 102, 1341 – 1343. 10.1111/j.1365-2141.1998.00921.x CASPubMedWeb of Science®Google Scholar Harrison, C.N., Chitolie, A., Carr, P., Dave, M., Mackie, I. & Machin, S.J. (1998b) Evaluation of risk factors for thrombosis in patients with essential thrombocythaemia. British Journal of Haematology, 101, 325 (Abstract). PubMedWeb of Science®Google Scholar Harrison, C.N., Gale, R.E., Machin, S.J. & Linch, D.C. (1999a) A large proportion of patients with a diagnosis of essential thrombocythaemia do not have a clonal disorder and may be at lower risk of thrombotic complications. Blood, 93, 417 – 424. CASPubMedWeb of Science®Google Scholar Harrison, C.N., Gale, R.E., Mire-Sluis, A., Pezella, F., Machin, S.J. & Linch, D.C. (1999b) Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value. British Journal of Haematology, 107, 139 – 147. 10.1046/j.1365-2141.1999.01667.x CASPubMedWeb of Science®Google Scholar Horikawa, Y., Matsumura, I., Hashimoto, K., Shiraga, M., Kosugi, S., Tadokoro, S., Kato, T., Miyazaki, H., Tomiyama, Y., Kurata, Y., Matsuzawa, Y. & Kanakura, Y. (1997) Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood, 90, 4031 – 4038. 10.1182/blood.V90.10.4031 CASPubMedWeb of Science®Google Scholar Jorgensen, M.J., Raskind, W.H., Wolff, J.F., Bachrach, H.R. & Kaushansky, K. (1998) Familial thrombocytosis associated with overproduction of thrombopoietin due to a novel splice donor site mutation. Blood, 92, 205a (Abstract). Web of Science®Google Scholar Juvonen, E., Ikkala, E., Oksanen, K. & Ruutu, T. (1993) Megakaryocyte and erythroid colony formation in essential thrombocythaemia and reactive thrombocytosis: diagnostic value and correlation to complications. British Journal of Haematology, 83, 192 – 197. 10.1111/j.1365-2141.1993.tb08271.x PubMedWeb of Science®Google Scholar Kaaja, R.J. & Leinonen, P.J. (1998) Successful pregnancies after recurrent abortions in mild essential thrombocythemia. Acta Obstetricia et Gynecologica Scandinavica, 77, 1022 – 1023. 10.1034/j.1600-0412.1998.771014.x CASPubMedWeb of Science®Google Scholar Kiladjian, J.J., El-kassar, N., Hetet, G., Briere, J., Grandchamp, B. & Gardin, C. (1997) Study of the thrombopoietin receptor in essential thrombocythemia. Leukemia, 11, 1821 – 1826. 10.1038/sj.leu.2400845 CASPubMedWeb of Science®Google Scholar Kondo, T., Okabe, M., Sanada, M., Kurosawa, M., Suzuki, S., Kobayashi, M., Hosokawa, M. & Asaka, M. (1998) Familial essential thrombocythemia associated with one-base deletion in the 5′-untranslated region of the thrombopoietin gene. Blood, 92, 1091 – 1096. 10.1182/blood.V92.4.1091 CASPubMedWeb of Science®Google Scholar Krsnik, I., Ferro, T., García Suárez, J., Vázquez Mazariego, Y. & Cabello, P. (2001) Translocation t(4;6) (q21;q27) in a case of primary thrombocythaemia in transformation. Clinical Laboratory Haematology, 23, 259 – 260. 10.1046/j.1365-2257.2001.00398.x CASPubMedWeb of Science®Google Scholar Kupferminc, M.J., Eldor, A., Steinman, N., Many, A., Bar-Am, A., Jaffa, A., Fait, G. & Lessing, J.B. (1999) Increased frequency of genetic thrombophilia in women with complications of pregnancy. New England Journal of Medicine, 340, 9 – 13.DOI: 10.1056/NEJM199901073400102 10.1056/NEJM199901073400102 CASPubMedWeb of Science®Google Scholar Kuroda, H., Sakamaki, S., Konuma, Y., Kusakabe, T., Akiyama, T., Hirayama, Y., Matsunga, T., Sasaki, K. & Niitsu, Y. (1999) Decrease of SMAD4 gene expression in patients with Essential Thrombocythaemia – an escape from suppression of megakaryopoiesis by TGF-β. Blood, 94, 3101a (Abstract). Google Scholar Kuter, D.J. & Rosenberg, R.D. (1995) The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood, 85, 2720 – 2730. 10.1182/blood.V85.10.2720.bloodjournal85102720 CASPubMedWeb of Science®Google Scholar Lahuerta-Palacios, J.J., Bornstein, R., Fernandez-Debora, F.J., Gutierrez-Rivas, E., Oritz, M.C., Larregla, S., Calandre, L. & Motero-Sastillo, J. (1988) Controlled and uncontrolled thrombocytosis its clinical role in essential thrombocythaemia. Cancer, 61, 1207 – 1212. 10.1002/1097-0142(19880315)61:6 3.0.CO;2-4 PubMedWeb of Science®Google Scholar Lengfelder, E., Hochhaus, A., Kronawitter, U., Hoche, D., Queisser, W., Jahn-Eder, M., Burkhardt, R., Reiter, A., Ansari, H. & Hehlmann, R. (1998) Should a platelet limit of 600 x 109/1 be used as a diagnostic criterion in essential thrombocythaemia? An analysis of the natural course including early stages. British Journal of Haematology, 100, 15 – 23.DOI: 10.1046/j.1365-2141.1998.00529.x 10.1046/j.1365-2141.1998.00529.x CASPubMedWeb of Science®Google Scholar Li, J., Xia, Y. & Kuter, D.J. (1996) Analysis of the thrombopoietin receptor (mpl) on platelets from normal and essential thrombocythemic patients. Blood, 88, 545a (Abstract). Google Scholar Li, J., Xia, Y. & Kuter, D.J. (2000) The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia. British Journal of Haematology, 111, 943 – 953. 10.1111/j.1365-2141.2000.02430.x CASPubMedWeb of Science®Google Scholar Lishner, M., Amato, D. & Farine, D. (1993) Different outcomes of pregnancy in women with essential thrombocytosis. Israel Journal of Medical Sciences, 29, 100 – 102. CASPubMedWeb of Science®Google Scholar Lofvenberg, E., Nordenson, I. & Wahlin, A. (1990a) Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. Cancer, Genetics and Cytogenetics, 49, 57 – 67. 10.1016/0165-4608(90)90164-6 PubMedWeb of Science®Google Scholar Lofvenberg, E., Wahlin, A., Roos, G. & Ost, A. (1990b) Reversal of myelofibrosis by hydroxyurea. European Journal of Haematology, 44, 33 – 38. 10.1111/j.1600-0609.1990.tb00344.x PubMedWeb of Science®Google Scholar Mage-Nativ, H., Stark, P., Kadosh, S., Weinshtock, M. & Shaklai, M. (2000) Hemostatic complications and role of aspirin in myeloproliferative disorders: results of long term follow up of 394 patients. Hematology Journal, 1, 75 (Abstract). Google Scholar Manoharan, A. & Pitney, W.R. (1984) Chemotherapy resolves symptoms and reverses marrow fibrosis in myelofibrosis. Scandinavian Journal of Haematology, 33, 453 – 459. 10.1111/j.1600-0609.1984.tb00724.x PubMedWeb of Science®Google Scholar Mazur, E.M., Rosmarin, A.G., Sohl, P.A., Newton, J.L. & Narendran, A. (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood, 79, 1931 – 1937. 10.1182/blood.V79.8.1931.1931 CASPubMedWeb of Science®Google Scholar Mercer, B., Drouin, J., Jolly, E. & D'Anjou, G. (1988) Primary thrombocythemia in pregnancy: a report of two cases. American Journal of Obstetrics and Gynecology, 159, 127 – 128. 10.1016/0002-9378(88)90507-8 PubMedWeb of Science®Google Scholar Mesa, R.A., Silverstein, M.N., Jacobsen, S.J., Wollan, P.C. & Tefferi, A. (1999) Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County Study, 1976–95. American Journal of Hematology, 61, 10 – 15. 10.1002/(SICI)1096-8652(199905)61:1 3.0.CO;2-I CASPubMedWeb of Science®Google Scholar Michiels, J.J. (1998) Essential thrombocythaemia is not associated with postpartum thrombosis or an increased risk of venous thromboembolism. Thrombocythemia Vera Study Group and European Working Group on Myeloproliferative Disorders. European Journal of Haematology, 60, 138 – 139. 10.1111/j.1600-0609.1998.tb01012.x CASPubMedWeb of Science®Google Scholar Michiels, J.J., Koudstaal, P.J., Mulder, A.H. & Van Vliet, H.H. (1993) Transient neurologic and ocular manifestations in primary thrombocythemia. Neurology, 43, 1107 – 1110. 10.1212/WNL.43.6.1107 PubMedWeb of Science®Google Scholar Millard, F.E., Hunter, C.S., Anderson, M., Edelman, M.J., Kosty, M.P., Luiken, G.A. & Marino, G.G. (1990) Clinical manifestations of essential thrombocythemia in young adults. American Journal of Hematology, 33, 27 – 31. 10.1002/ajh.2830330106 PubMedWeb of Science®Google Scholar Moliterno, A.R. & Spivak, J.L. (1999) Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera. Blood, 94, 2555 – 2561. 10.1182/blood.V94.8.2555.420k14_2555_2561 CASPubMedWeb of Science®Google Scholar Moliterno, A.R., Hankins, W.D. & Spivak, J.L. (1998) Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera [see comments]. New England Journal of Medicine, 338, 572 – 580.DOI: 10.1056/NEJM199802263380903 10.1056/NEJM199802263380903 CASPubMedWeb of Science®Google Scholar Murphy, S., Peterson, P., Iland, H. & Laszlo, J. (1997) Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment. Seminars in Hematology, 34, 29 – 39. PubMedWeb of Science®Google Scholar Neri, A., Fracchiolla, N.S., Radaelli, F., Boletini, A., Ribera, S., Migliorini, C., Trecca, D. & Maiolo, A.T. (1996) p53 tumour suppressor gene and RAS oncogenes: molecular analysis in the chronic and leukaemic phases of essential thrombocythaemia. British Journal of Haematology, 93, 670 – 673. 10.1046/j.1365-2141.1996.d01-1690.x CASPubMedWeb of Science®Google Scholar Niitsu, Y., Sakamaki, S., Kuroda, H., Matsunaga, T., Hirayama, Y., Kusabe, T., Akiyama, T. & Sasaki, K. (1998) Mutation of the type II TGF-b receptor gene in patients with Essential Thrombocythaemia may cause an escape from suppression of megakaryopoiesis by TGF-b. Blood, 92, 1746a (Abstract). Google Scholar Nurden, P., Bihour, C., Smith, M., Raymond, J.M. & Nurden, A.T. (1996) Platelet activation and thrombosis: studies in a patient with essential thrombocythemia. American Journal of Hematology, 51, 79 – 84.DOI: 10.1002/(SICI)1096-8652(199601)51:1 3.0.CO;2-6 10.1002/(SICI)1096-8652(199601)51:1 3.0.CO;2-6 PubMedWeb of Science®Google Scholar Ozer, F.L., Wayne, E.I., Miesch, D.C. & Levin, W.C. (1960) Primary haemorrhagic thrombocythaemia. American Journal of Medicine, 28, 807 – 823. Google Scholar Pagliaro, P., Arrigoni, L., Muggiasca, M.L., Poggio, M., Russo, U. & Rossi, E. (1996) Primary thrombocythemia and pregnancy: treatment and outcome in fifteen cases. American Journal of Hematology, 53, 6 – 10.DOI: 10.1002/(SICI)1096-8652(199609)53:1 3.3.CO;2-N 10.1002/(SICI)1096-8652(199609)53:1 3.0.CO;2-V PubMedWeb of Science®Google Scholar Pearson, T.C., Bareford, D., Craig, J., Egan, E.L., Green, A.R., Lucas, G.S., Ludlam, C.A., McMullin, M.-F., Messinezy, M., Oscier, D.G. & Reilly, J.T. (1999) The management of 'low-risk' and 'intermediate-risk' patients with primary thrombocythaemia. MPD (UK) Study Group. British Journal of Haematology, 106, 833 – 834. 10.1046/j.1365-2141.1999.01653.x CASPubMedWeb of Science®Google Scholar Pitcher, L., Taylor, K., Nichol, J., Selsi, D., Rodwell, R., Marty, J., Taylor, D., Wright, S., Moore, D., Kelly, C. & Rentoul, A. (1997) Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia. British Journal of Haematology, 99, 929 – 932. 10.1046/j.1365-2141.1997.4633267.x CASPubMedWeb of Science®Google Scholar Rai, R., Cohen, H., Dave, M. & Regan, L. (1997) Randomized controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). British Medical Journal, 314, 253 – 257. 10.1136/bmj.314.7076.253 PubMedWeb of Science®Google Scholar Randi, M.L., Rossi, C., Fabris, F. & Girolami, A. (2000) Essential thrombocythemia in young adults: major thrombotic complications and complications during pregnancy – a follow-up study in 68 patients. Clinical and Applied Thrombosis/Hemostasis, 6, 31 – 35. 10.1177/107602960000600105 CASPubMedWeb of Science®Google Scholar Regan, L. (1992) Recurrent miscarriage. Practitioner, 236, 383 – 386 (Review). CASPubMedWeb of Science®Google Scholar Regev, A., Stark, P., Blickstein, D. & Lahav, M. (1997) Thrombotic complications in essential thrombocythaemia with relatively low platelet counts. American Journal of Haematology, 56, 168 – 172. 10.1002/(SICI)1096-8652(199711)56:3 3.0.CO;2-W CASPubMedWeb of Science®Google Scholar Rintelen, C., Pabinger, I., Knobl, P., Geissler, K., Jager, K., Lechner, K., Mannhalter, Ch & Gisslinger, H. (1996) Factor V Leiden mutation is possibly an additional risk factor for venous thromboembolism in essential thrombocythaemia and polycythaemia vera. British Journal of Haematology, 93, 5 (Abstract). Google Scholar Rozman, C., Giralt, M., Feliu, E., Rubio, D. & Cortes, M.-T. (1991) Life expectancy of patients with chronic non-leukemia myeloproliferative disorders. Cancer, 67, 2658 – 2663. 10.1002/1097-0142(19910515)67:10 3.0.CO;2-C PubMedWeb of Science®Google Scholar Ruggeri, M., Finazzi, G., Tosetto, A., Riva, S., Rodeghiero, F. & Barbui, T. (1998) No treatment for low-risk thrombocythaemia: results from a prospective study. British Journal of Haematology, 103, 772 – 777. 10.1046/j.1365-2141.1998.01021.x CASPubMedWeb of Science®Google Scholar Sacchi, S., Vinci, G., Gugliotta, L., Rupoli, S., Gargantini, L., Martinelli, V., Baravelli, S., Lazzarino, M. & Finazzi, G. for GIMMC (2000) Diagnosis of essential thrombocythaemia at platelet counts between 400 and 600 x 109/L. Haematologica, 85, 492 – 495. CASPubMedWeb of Science®Google Scholar Sakamaki, S., Hirayama, Y., Matsunaga, T., Kuroda, H., Kusakabe, T., Akiyama, T., Konuma, Y., Sasaki, K., Tsuji, N., Okamoto, T., Kobune, M., Kogawa, K., Kato, J., Takimoto, R., Koyama, R. & Niitsu, Y. (1999) Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity. Blood, 94, 1961 – 1970. 10.1182/blood.V94.6.1961 CASPubMedWeb of Science®Google Scholar Sanada, M. (1989) Three successful pregnancies in a woman with essential thrombocythemia. European Journal of Haematology, 42, 215 – 216. 10.1111/j.1600-0609.1989.tb01215.x CASPubMedWeb of Science®Google Scholar Schafer, A.I. (1984) Bleeding and thrombosis in the myeloproliferative disorders. Blood, 64, 1 – 12. 10.1182/blood.V64.1.1.1 CASPubMedWeb of Science®Google Scholar Scheffer, M.G., Michiels, J.J., Simoons, M.L. & Roelandt, J.R.T.C. (1991) Thrombocythaemia and coronary artery disease. American Heart Journal, 122, 573 – 576. 10.1016/0002-8703(91)91019-J CASPubMedWeb of Science®Google Scholar Shpilberg, O., Shimon, I., Sofer, O., Dolitski, M. & Ben-Bassat, I. (1996) Transient normal platelet counts and decreased requirement for interferon during pregnancy in essential thrombocythaemia. British Journal of Haematology, 92, 491 – 493. 10.1046/j.1365-2141.1996.d01-1476.x PubMedWeb of Science®Google Scholar Silverstein, M.N. & Tefferi, A. (1999) Treatment of essential thrombocythemia with anagrelide. Seminars in Hematology, 36, 23 – 25. CASPubMedWeb of Science®Google Scholar Snethlage, W. & Ten Cate, J.W. (1986) Thrombocythaemia and recurrent late abortions: normal outcome of pregnancies after antiaggregatory treatment. Case report. British Journal of Obstetrics and Gynaecology, 93, 386 – 388. CASPubMedWeb of Science®Google Scholar Solal-Celigny, P., Fernandez, H. & Tertian, G. (1992) Pregnancy in patients with essential thrombocythemia. Three cases. La Presse Medicale, 21, 2085 – 2088. CASPubMedWeb of Science®Google Scholar Solberg, Jr, L.A., Tefferi, A., Oles, K.J., Tarach, J.S., Petitt, R.M., Forstrom, L.A. & Silverstein, M.N. (1997) The effects of anagrelide on human megakaryocytopoiesis. British Journal of Haematology, 99, 174 – 180. 10.1046/j.1365-2141.1997.3503164.x CASPubMedWeb of Science®Google Scholar Souyri, M., Vigon, I., Penciolelli, J.F., Heard, J.M., Tambourin, P. & Wendling, F. (1990) A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell, 63, 1137 – 1147. 10.1016/0092-8674(90)90410-G CASPubMedWeb of Science®Google Scholar Sterkers, Y., Preudhomme, C., Lai, J.L., Demory, J.L., Caulier, M.T., Wattel, E., Bordessoule, D., Bauters, F. & Fenaux, P. (1998) Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea: high proportion of cases with 17p deletion. Blood, 91, 616 – 622. 10.1182/blood.V91.2.616 CASPubMedWeb of Science®Google Scholar Storen, E.C. & Tefferi, A. (2001) Long-term use of anagrelide in young patients with essential thrombocythaemia. Blood, 97, 863 – 866. 10.1182/blood.V97.4.863 CASPubMedWeb of Science®Google Scholar Sud, R., Gale, R.E., Harrison, C.N., Machin, S.J. & Linch, D.C. (2000) 'Mutations in the TGFβRII gene are unlikely to be responsible for the reduced sensitivity to TGFβ in megakaryocytes from patients with essential thrombocythaemia'. Blood, 96 (Suppl. 1, Part 1, 743a), 3212 (Abstract). Google Scholar Tahara, T., Usuki, K., Sato, H., Ohashi, H., Morita, H., Tsumura, H., Matsumoto, A., Miyazaki, H., Urabe, A. & Kato, T. (1996) A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. British Journal of Haematology, 93, 783 – 788. 10.1046/j.1365-2141.1996.d01-1741.x CASPubMedWeb of Science®Google Scholar Tartaglia, A.P., Goldberg, J.D., Berk, P.D. & Wasserman, L.R. (1986) Adverse effects of antiaggregating platelet therapy in the treatment of polycythaemia vera. Seminars in Hematology, 23, 172 – 176. PubMedWeb of Science®Google Scholar Taylor, K., Taylor, D., Favot, P., Rodwell, R., Pitcher, L., Coulston, J., Wright, S., Kelly, C., Marty, J. & Nichol, J. (1996) Failure to show molecular evidence for involvement of thrombopoietin and c-Mpl genes in essential thrombocythaemia. Blood, 88 (Suppl. 1), 205b (Abstract). Google Scholar Tefferi, A., Solberg, L.A. & Silverstein, M.N. (2000) A clinical update in polycythaemia vera and essential thrombocythaemia. American Journal of Medicine, 109, 141 – 149. 10.1016/S0002-9343(00)00449-6 CASPubMedWeb of Science®Google Scholar Tefferi, A., Fonseca, R., Pereira, D.L. & Hoagland, H.C. (2001) A long-term retrospective study of young women with essential thrombocythaemia. Mayo Clinic Proceedings, 76, 22 – 28. 10.4065/76.1.22 CASPubMedWeb of Science®Google Scholar Thiele, J., Kvasnicka, H.M., Zankovich, R. & Diehl, V. (2000) Relevance of bone marrow features in the differential diagnosis between essential thrombocythemia and early stage idiopathic myelofibrosis. Haematologica, 85, 1126 – 1134. CASPubMedWeb of Science®Google Scholar Van der Pette, J.E., Prochazka, A.V., Pearson, T.C., Singh, A.K., Dickson, E.R. & Wetherley-Mein, G. (1986) Primary thrombocythaemia treated with busulphan. British Journal of Haematology, 62, 229 – 237. 10.1111/j.1365-2141.1986.tb02926.x PubMedWeb of Science®Google Scholar Westwood, N.B. & Pearson, T.C. (1996) Diagnostic applications of haemopoietic progenitor culture techniques in polycythaemias and thrombocythaemias. Leukemia and Lymphoma, 22, 95 – 103. 10.3109/10428199609074366 PubMedWeb of Science®Google Scholar Wiestner, A., Schlemper, R.J., Van Der Maas, A.P. & Skoda, R.C. (1998) An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nature Genetics, 18, 49 – 52. 10.1038/ng0198-49 CASPubMedWeb of Science®Google Scholar Willoughby, S.J., Fairhead, S., Woodcock, B.E. & Pearson, T.C. (1997) Postpartum thrombosis in primary thrombocythaemia. European Journal of Haematology, 59, 121 – 123. 10.1111/j.1600-0609.1997.tb00736.x CASPubMedWeb of Science®Google Scholar Wright, C.A. & Tefferi, A. (2001) A single institutional experience with 43 pregnancies in essential thrombocythemia. European Journal of Haematology, 66, 152 – 159 (Review).DOI: 10.1034/j.1600-0609.2001.00367.x 10.1034/j.1600-0609.2001.00367.x CASPubMedWeb of Science®Google Scholar Zauli, G., Visani, G., Catani, L., Vianelli, N., Gugliotta, L. & Capitani, S. (1993) Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet-derived transforming growth factor beta 1, produced in normal amount, in patients with essential thrombocythaemia. British Journal of Haematology, 83, 14 – 20. 10.1111/j.1365-2141.1993.tb04624.x CASPubMedWeb of Science®Google Scholar Citing Literature Volume117, Issue4June‐II 2002Pages 796-808 ReferencesRelatedInformation
Referência(s)