Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark

2010; UNIVERSIDADE DE SÃO PAULO; Volume: 46; Issue: 3 Linguagem: Inglês

10.1590/s1984-82502010000300008

2175-9790

Pablinny Moreira Galdino, Marcus Vinícius Mariano Nascimento, Fábio Borges de Sousa, Reginaldo Nassar Ferreira, José Realino de Paula, Élson Alves Costa,

Biochemical Analysis and Sensing Techniques

Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of rearings, number of invaded squares, and increased immobility time compared to control animals. In the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increased sleeping time. In the rota-rod test, no changes in the studied parameters were observed. In the elevated plus maze, HEP increased the percentage time and percentage entries in the open arms, indicating that this extract exerts an anxiolytic-like activity.