Portal de Periódicos da CAPES

Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer

2012; Springer Science+Business Media; Volume: 61; Issue: 10 Linguagem: Inglês

10.1007/s00262-012-1225-5

1432-0851

Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Masataka Matsumoto, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Kosei Maemura, Yuko Kijima, Akihiro Nakajo, Tetsuhiro Owaki, Shinichi Ueno, Shuichi Hokita, Shoji Natsugoe,

T-cell and B-cell Immunology

Since antitumor immune reactions between tumors and intratumoral immunocytes have been verified in several human tumors, immunological therapeutic strategies must be considered to obtain the proper efficacy of tumor shrinkage under these conditions. Human leukocyte antigen (HLA) class I expression in cancer cells and degree of infiltration of regulatory T cells (Tregs) in the stroma have been regarded as important markers of antitumor immune reactions in the context of independent immunological mechanisms. In the current study, we investigated HLA class I expression and Treg cells infiltration in gastric cancer and discussed the clinical implications of this combinatory analysis in gastric cancer.