Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms
2009; Elsevier BV; Volume: 1216; Issue: 32 Linguagem: Inglês
10.1016/j.chroma.2009.06.036
ISSN1873-3778
AutoresGerhard Laus, Max Andre, G. Bentivoglio, Herwig Schottenberger,
Tópico(s)Advanced Chemical Sensor Technologies
Resumo1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor pressure such as dimethylsulfoxide, N-methylpyrrolidone, sulfolane, tetralin, and ethylene glycol in a realistic matrix of commonly used excipients (carboxymethylcellulose, magnesium stearate, guar flour, and corn starch) in pharmaceutical products. Limits of quantification and limits of detection were in the low microgram per gram range. The detection of traces of sulfolane in a real sample of tablets containing the drug cefpodoxim proxetil demonstrated the applicability of the method.
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