Straightforward and Highly Efficient Catalyst-Free One-Pot Synthesis of Dithiocarbamates under Solvent-Free Conditions
2006; American Chemical Society; Volume: 8; Issue: 23 Linguagem: Inglês
10.1021/ol0620141
ISSN1523-7060
AutoresNajmedin Azizi, Fezzeh Aryanasab, Mohammad R. Saidi,
Tópico(s)Multicomponent Synthesis of Heterocycles
ResumoA highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries.
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