The Syndrome of Kaposi's Sarcoma and Opportunistic Infections: An Epidemiologically Restricted Disorder of Immunoregulation
1982; American College of Physicians; Volume: 96; Issue: 6_part_1 Linguagem: Inglês
10.7326/0003-4819-96-6-777
ISSN1539-3704
Autores Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoEditorials1 June 1982The Syndrome of Kaposi's Sarcoma and Opportunistic Infections: An Epidemiologically Restricted Disorder of ImmunoregulationFREEANTHONY S. FAUCI, M.D.ANTHONY S. FAUCI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-777 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn June and July of 1981 the Centers for Disease Control (CDC) reported to the medical community the alarming and unprecedented occurrence of Kaposi's sarcoma,Pneumocystis cariniipneumonia, and other severe opportunistic infections among apparently previously healthy homosexual men in the United States, with a concentration of cases in New York and California (1, 2). Soon thereafter more detailed reports appeared in the literature clearly documenting this unique pattern of disease (3-6). The number of cases being recognized is increasing, with at least one case per day being reported to the CDC. The current total is 290 recognized cases, making...References1. . Pneumocystis pneumonia—Los Angeles. Morbid Mortal Weekly Rep. 1981;30:250-2. MedlineGoogle Scholar2. . Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men—New York City and California. Morbid Mortal Weekly Rep. 1981;30:305-8. MedlineGoogle Scholar3. HYMESCHEUNGGREENE KTJ. Kaposi's sarcoma in homosexual men—a report of eight cases. Lancet. 1981;2:598-600. CrossrefMedlineGoogle Scholar4. GOTTLIEBSCHROFFSCHANKER MRH. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med. 1981;305:1425-31. CrossrefMedlineGoogle Scholar5. MASURMICHELISGREENE HMJ. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med. 1981;305:1431-8. CrossrefMedlineGoogle Scholar6. SIEGALLOPEZHAMMER FCG. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981;305:1439-44. CrossrefMedlineGoogle Scholar7. RINALDOCARNEYRICHTERBLACKHIRSCH CWBPM. Mechanisms of immunosuppression in cytomegaloviral mononucleosis. J Infect Dis. 1980;141:488-95. CrossrefMedlineGoogle Scholar8. SPENCER E. Clinical aspects of cytomegalovirus infection in kidney-graft recipients. Scand J Infect Dis. 1974;6:315-23. CrossrefMedlineGoogle Scholar9. MILDVANMATHURENLOW DUR. Opportunistic infections and immune deficiency in homosexual men. Ann Intern Med. 1982; 96(6 pt 1):700-4. LinkGoogle Scholar10. FOLLANSBEEBUSCHWOFSY SDC. An outbreak of Pneumocystis carinii pneumonia in homosexual men. Ann Intern Med. 1982;96(6 pt 1):705-13. LinkGoogle Scholar11. MORRISDISTENFELDAMOROSIKARPATKIN LAES. Autoimmune thrombocytopenic purpura in homosexual men. Ann Intern Med. 1982;96(6 pt 1):714-7. LinkGoogle Scholar12. FRIEDMAN-KIENLAUBENSTEINRUBENSTEIN ALP. Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med. 1982;96(6 pt 1):693-700. LinkGoogle Scholar13. REINHERZSCHLOSSMAN ES. The characterization and function of human immunoregulatory T lymphocyte subsets. Immunol Today. 1981;2:69-75. CrossrefMedlineGoogle Scholar14. . Epidemiologic aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections. N Engl J Med. 1982;306:248-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPotential Role of Interferon-Gamma in Human Immunodeficiency Virus-Associated DiseaseWhat Recent History Has Taught Us About Responding to Emerging Infectious Disease ThreatsCatharine I. Paules, MD, Robert W. 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