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Direct excitant action of convulsant barbiturates

1981; Birkhäuser; Volume: 37; Issue: 2 Linguagem: Inglês

10.1007/bf01963215

0014-4754

Peter R. Andrews, Richard H. Evans, Graham A.R. Johnston, Max Willow,

Pesticide Exposure and Toxicity

5-(2-cyclohexylideneethyl)-5-ethylbarbituric acid (CHEB) and other convulsant barbiturates produced depolarization of isolated dorsal root fibres and other unmyelinated nerves from the rat. CHEB-induced depolarizations, unlike kainate-induced depolarizations were abolished by omission of Ca2+ from, or addition of ruthenium red (5 μM) to, the bathing medium.