α-Fodrin (brain spectrin) immunocytochemical localization in rat vestibular hair cells
1988; Elsevier BV; Volume: 93; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(88)90004-3
ISSN1872-7972
AutoresEric Scarfone, Danielle Demêmes, Dominique Perrin, Dominique Aunis, Alain Sans,
Tópico(s)Vestibular and auditory disorders
ResumoThe presence of a spectrin-related protein in rat vestibular sensory receptors was demonstrated by immunocytochemistry and immunoblotting using affinity purified anti alpha-fodrin antibodies. Intense immunoreactivity was found in the apical pole of sensory hair cells where it seems to be concentrated in the cuticular plate. In contrast, alpha-fodrin immunoreactivity was absent from the stereocilia. We suggest that a spectrin-related protein participates in the organization of the cuticular plate of vestibular hair cells by cross-linking actin filaments as well as by anchoring the cuticular plate to the apical cell membrane.
Referência(s)