Artigo Revisado por pares

α-Fodrin (brain spectrin) immunocytochemical localization in rat vestibular hair cells

1988; Elsevier BV; Volume: 93; Issue: 1 Linguagem: Inglês

10.1016/0304-3940(88)90004-3

ISSN

1872-7972

Autores

Eric Scarfone, Danielle Demêmes, Dominique Perrin, Dominique Aunis, Alain Sans,

Tópico(s)

Vestibular and auditory disorders

Resumo

The presence of a spectrin-related protein in rat vestibular sensory receptors was demonstrated by immunocytochemistry and immunoblotting using affinity purified anti alpha-fodrin antibodies. Intense immunoreactivity was found in the apical pole of sensory hair cells where it seems to be concentrated in the cuticular plate. In contrast, alpha-fodrin immunoreactivity was absent from the stereocilia. We suggest that a spectrin-related protein participates in the organization of the cuticular plate of vestibular hair cells by cross-linking actin filaments as well as by anchoring the cuticular plate to the apical cell membrane.

Referência(s)
Altmetric
PlumX