Propranolol:Methacrylic Acid Copolymer Binding Interaction
1991; Elsevier BV; Volume: 80; Issue: 2 Linguagem: Inglês
10.1002/jps.2600800220
ISSN1520-6017
AutoresHyuk‐Koo Lee, Joseph Hajdu, Paul McGoff,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoAbstract The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol-HCl to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.
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