Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein
1999; Elsevier BV; Volume: 259; Issue: 2 Linguagem: Inglês
10.1016/s0304-3940(98)00890-8
ISSN1872-7972
AutoresTetsuaki Arai, Kenji Uéda, Kenji Ikeda, Haruhiko Akiyama, Chie Haga, Hiromi Kondo, Noriomi Kuroki, Kazuhiro Niizato, Shuji Iritani, Kuniaki Tsuchiya,
Tópico(s)Neurological disorders and treatments
ResumoArgyrophilic glial inclusions occur in the midbrain of patients with Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). These inclusions are immunohistochemically positive for NACP/alpha-synuclein but negative for tau protein. The results of the present study suggest that a primary degenerative process involves NACP/alpha-synuclein in PD and DLBD and that the process takes place not only in neurons but also in glial cells. Argyrophilic cytoplasmic inclusions, both glial and neuronal, in a variety of degenerative diseases may be grouped into two major categories; one related to aggregates of abnormally phosphorylated tau protein and the other to unusual accumulations of NACP/alpha-synuclein.
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