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Motor perseveration is an early sign of Parkinson’s disease

2001; Lippincott Williams & Wilkins; Volume: 57; Issue: 11 Linguagem: Inglês

10.1212/wnl.57.11.2111

1526-632X

Diederick Stoffers, Henk W. Berendse, J.B. Deijen, E.Ch. Wolters,

Autism Spectrum Disorder Research

Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to switch cortical behavioral programs in PD. An impairment of random motor generation appears to be a very early feature of PD.