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Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

2013; Cell Press; Volume: 18; Issue: 4 Linguagem: Inglês

10.1016/j.cmet.2013.09.004

1932-7420

Yolanda Jiménez, Julie A. Mattison, Kevin J. Pearson, Alejandro Martín‐Montalvo, Hector H. Palacios, Alex M. Sossong, Theresa M. Ward, Caitlin M. Younts, Kaitlyn N. Lewis, Joanne Allard, Dan L. Longo, Jonathan P. Belman, Marı́a M. Malagón, Plácido Navas, Mitesh Sanghvi, Ruin Moaddel, Edward M. Tilmont, Richard Herbert, Christopher H. Morrell, Josephine M. Egan, Joseph A. Baur, Luigi Ferrucci, Jonathan Bogan, Michel Bernier, Rafael de Cabo,

Adipokines, Inflammation, and Metabolic Diseases

Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.