Cellular correlates to spatial learning in the rat hippocampus
1996; Elsevier BV; Volume: 90; Issue: 5-6 Linguagem: Inglês
10.1016/s0928-4257(97)87917-x
ISSN1769-7115
AutoresP. Andersen, Edvard I Moser, May‐Britt Moser, Mari Trommald,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoLearning through exploration gives increased synaptic field potentials in the perforant path/dentate synapses, largely due to an activity-dependent brain temperature increase. After temperature compensation, spatial learning was associated with small, but significant, STP-like changes of the field potential lasting 20-30 min. A group of spatially trained adult rats showed faster spatial learning and about 10% higher basal dendritic spine density (LY-filled) compared to two control groups. With unchanged dendritic length and branching pattern, the results suggest the formation of new synapses.
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