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Microbial epoxide hydrolases for preparative biotransformations

2001; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1016/s0958-1669(01)00262-2

1879-0429

Andreas Steinreiber, Kurt Faber,

Pharmacogenetics and Drug Metabolism

Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which furnishes the corresponding vicinal diol and remaining non-hydrolysed epoxide in nonracemic form, enantioconvergent processes are possible: these are highly attractive as they lead to the formation of a single enantiomeric diol from a racemic oxirane. The data accumulated over recent years reveal a common picture of the substrate structure selectivity pattern of microbial epoxide hydrolases and indicate that substrates of various structural types can be selectively hydrolysed with enzymes from certain microbial sources.