Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
2015; American Association for the Advancement of Science; Volume: 347; Issue: 6217 Linguagem: Inglês
10.1126/science.1260972
ISSN1095-9203
AutoresLing‐juan Zhang, Christian F. Guerrero‐Juarez, Tissa Hata, Sagar P. Bapat, Raúl Ramos, Maksim V. Plikus, Richard L. Gallo,
Tópico(s)Acne and Rosacea Treatments and Effects
ResumoSkin infection triggers fat responses Obesity is associated with chronic inflammation, but does fat tissue offer protection during infection? Zhang et al. noticed that the fat layers in the skin of mice thickened after inoculation with the pathogenic bacterium Staphylococcus aureus (see the Perspective by Alcorn and Kolls). Mutant mice incapable of forming new fat cells were more susceptible to infection. The differentiating fat cells secreted a small-molecule peptide called cathelicidin, specifically in response to the infection. By contrast, mature fat cells produce less cathelicidin, and are thus less protective. Science , this issue p. 67 ; see also p. 26
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