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An Approach to Evolutionary Relationships of Mammalian DNA Viruses Through Analysis of the Pattern of Nearest Neighbor Base Sequences

1966; Cold Spring Harbor Laboratory Press; Volume: 31; Linguagem: Inglês

10.1101/sqb.1966.031.01.094

1943-4456

H. Subak-Sharpe, Robert R. Bürk, L. V. Crawford, Jo Morrison, Jennifer M. Hay, H.M. Keir,

Plant Virus Research Studies

The essential early features of successful infection of a host cell by a DNA virus genome as generally accepted are the following: First, some or all of the virus genome is transcribed into RNA by the DNA-dependent RNA polymerase of the host cell. Some or all of this virus-specified RNA must have messenger function. This RNA is next translated by the pre-existing translation apparatus of the host cell. As a result, new virus-specified polypeptides are formed on the host ribosomes, and successful completion of these polypeptides results in the formation of new proteins. The metabolism of the infected cell then undergoes a sequence of changes—which differ for different viruses and which are not relevant here—leading to the production of complete progeny virus particles. It may be asked whether it is reasonable to assume that a cell's translation apparatus will always be well equipped to translate the nucleic acid of an...