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Ultrasmall Cu 2‐ x S Nanodots for Highly Efficient Photoacoustic Imaging‐Guided Photothermal Therapy

2015; Wiley; Volume: 11; Issue: 19 Linguagem: Inglês

10.1002/smll.201403249

1613-6829

Juan Mou, Pei Li, Chengbo Liu, Hui‐Xiong Xu, Liang Song, Jin Wang, Kun Zhang, Yu Chen, Jianlin Shi, Hangrong Chen,

Extracellular vesicles in disease

Monodisperse, ultrasmall (<5 nm) Cu 2− x S nanodots ( u ‐Cu 2− x S NDs) with significantly strong near‐infrared absorption and conversion are successfully demonstrated for effective deep‐tissue photoacoustic imaging‐guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u ‐Cu 2− x S NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u ‐Cu 2− x S NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging‐guided photothermal therapy based on u ‐Cu 2− x S NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.