Portal de Periódicos da CAPES

Hydroxyproline and Collagen Metabolism: Clinical Implications: Combined Clinical Staff Conference at the National Institutes of Health

1965; American College of Physicians; Volume: 63; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-63-4-672

1539-3704

Albert Sjoerdsma,

Connective tissue disorders research

Clinical Staff Conference1 October 1965Hydroxyproline and Collagen MetabolismCombined Clinical Staff Conference at the National Institutes of HealthALBERT SJOERDSMA, M.D., PH.D., SIDNEY UDENFRIEND, PH.D., HARRY KEISER, M.D., E. CARWILE LEROY, M.D.ALBERT SJOERDSMA, M.D., PH.D.Search for more papers by this author, SIDNEY UDENFRIEND, PH.D.Search for more papers by this author, HARRY KEISER, M.D.Search for more papers by this author, E. CARWILE LEROY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Albert Sjoerdsma: Collagen is one of the scleroproteins and accounts for about 30% of the body proteins. It exerts an architectural function throughout the body, most notably in skin, tendons, cartilage, blood vessels, connective tissue, organ capsules, and bone matrix. It confers the ultimate in "togetherness" and, except in psychiatry, is responsible for making one an "intact" individual. It is of fundamental importance in the pathogenesis of various diseases, in the processes of growth and aging, and of course in the healing of wounds. Use of the term "collagen disease" in clinical medicine has served at least as a...References1. SCHMITT FO: Giant molecules in cells and tissues. Sci. Amer. 197: 204, 1957. CrossrefGoogle Scholar2. GROSS J: Collagen. Sci. Amer. 204: 121, 1961. CrossrefMedlineGoogle Scholar3. HARKNESSMARKOMUIRNEUBERGER RDAMHMA: The metabolism of collagen and other proteins of the skin of rabbits. Biochem. J. 56: 558, 1954. CrossrefMedlineGoogle Scholar4. JACKSON DS: Connective tissue growth stimulated by carrageenin. 1. The formation and removal of collagen. Biochem. J. 65: 277, 1957. CrossrefMedlineGoogle Scholar5. STETTEN MR: Some aspects of the metabolism of hydroxyproline, studied with the aid of isotopic nitrogen. J. Biol. Chem. 181: 31, 1949. CrossrefMedlineGoogle Scholar6. MITOMASMITHFRIEDBERGRAYFORD CTEFCR: Incorporation of hydroxyproline into tissue proteins by chick embryos. J. Biol. Chem. 234: 78, 1959. CrossrefMedlineGoogle Scholar7. PROCKOPKAPLANUDENFRIEND DAS: Oxygen-18 studies on the conversion of proline to hydroxyproline. Biochem. Biophys. Res. Commun. 9: 162, 1962. CrossrefMedlineGoogle Scholar8. FUJIMOTOTAMIYA DN: Incorporation of 18O from air into hydroxyproline by chick embryo. Biochem. J. 84: 333, 1962. CrossrefMedlineGoogle Scholar9. PETERKOFSKYUDENFRIEND BS: Conversion of proline to collagen hydroxyproline in a cell-free system from chick embryo. J. Biol. Chem. 238: 3966, 1963. CrossrefMedlineGoogle Scholar10. MANNERGOULD GBS: Collagen biosynthesis. The formation of hydroxyproline and soluble-ribonucleic acid complexes of proline and hydroxyproline by chick embryo in vivo and by a subcellular chick-embryo system. Biochim. Biophys. Acta 72: 243, 1963. CrossrefGoogle Scholar11. CORONADOMARDONESALLENDE AEJE: Isolation of hydroxylysyl-sRNA and hydroxyprolyl-sRNA in a chick embryo system. Biochem. Biophys. Res. Commun. 13: 75, 1963. CrossrefMedlineGoogle Scholar12. JACKSONWATKINSWINKLER DSDA: Formation of s-RNA hydroxyproline in chick-embryo and wound granulation tissue. Biochim. Biophys. Acta 87: 152, 1964. MedlineGoogle Scholar13. PETERKOFSKYUDENFRIEND BS: Enzymatic hydroxylation of proline in microsomal polypeptide leading to formation of collagen. Proc. Nat. Acad. Sci. USA 53: 335, 1965. CrossrefMedlineGoogle Scholar14. GOTTLIEBUDENFRIEND AS: A hydroxyproline deficient intermediate in collagen synthesis. Fed. Proc. 24: 358, 1965. Google Scholar15. THOMASELSDENPARTRIDGE JDFSM: Partial structure of two major degradation products from the cross-linkages in elastin. Nature (London) 200: 651, 1963. CrossrefMedlineGoogle Scholar16. GOTTLIEBFUJITAUDENFRIENDWITKOP AYSB: Incorporation of cis and trans-4-fluoro-L-prolines into proteins and hydroxylation of the trans isomer during collagen biosynthesis. In preparation. Google Scholar17. KAUFMAN S: Aromatic hydroxylations, in Oxygenases, edited by HAYAISHI, O., Academic Press, New York, 1962, p. 129. CrossrefGoogle Scholar18. RENSONWEISSBACHUDENFRIEND JHS: On the mechanism of oxidative change of arylalkyl ethers by liver microsomes. J. Mol. Pharm. In press. Google Scholar19. SJOERDSMADAVIDSONUDENFRIENDMITOMA AJDSC: Increased excretion of hydroxyproline in Marfan's syndrome. Lancet 2: 994, 1958. CrossrefMedlineGoogle Scholar20. MITOMASMITHDAVIDSONUDENFRIENDDACOSTASJOERDSMA CTEJDSFMA: Improvements in methods for measuring hydroxyproline. Application to human urine. J. Lab. Clin. Med. 53: 970, 1959. MedlineGoogle Scholar21. MEILMANURIVETSKYRAPOPORT EMMCM: Urinary hydroxyproline peptides. J. Clin. Invest. 42: 40, 1963. CrossrefMedlineGoogle Scholar22. JONESBERGMANKITTNERPIGMAN CRMWPJW: Urinary hydroxyproline excretion in Marfan's syndrome as compared with age matched controls. Proc. Soc. Exp. Biol. Med. 116: 931, 1964. CrossrefMedlineGoogle Scholar23. MARTINMERGENHAGENPROCKOP GRSEDJ: Influence of scurvy and lathyrism (odoratism) on hydroxyproline excretion. Nature (London) 191: 1008, 1961. CrossrefMedlineGoogle Scholar24. JASINZIFF HEM: Relationship between soluble collagen and urinary hydroxyproline in the lathyritic rat. Proc. Soc. Exp. Biol. Med. 110: 837, 1962. CrossrefMedlineGoogle Scholar25. HARDING JJ: The components of gelatins derived from soluble collagens. J. Soc. Leather Trades' Chem. 48: 160, 1964. Google Scholar26. SMILEYZIFF JDM: Urinary hydroxyproline excretion and growth. Physiol. Rev. 44: 30, 1964. CrossrefMedlineGoogle Scholar27. LINDSTEDTPROCKOP SDJ: Isotopic studies on urinary hydroxyproline as evidence for rapidly catabolized forms of collagen in the young rat. J. Biol. Chem. 236: 1399, 1961. CrossrefMedlineGoogle Scholar28. PROCKOP DJ: Isotopic studies on collagen degradation and the urine excretion of hydroxyproline. J. Clin. Invest. 43: 453, 1964. CrossrefMedlineGoogle Scholar29. PROCKOPKEISERSJOERDSMA DJHRA: Gastrointestinal absorption and renal excretion of hydroxyproline peptides. Lancet 2: 527, 1962. CrossrefMedlineGoogle Scholar30. JASINFINKWISEZIFF HECWWM: Relationship between urinary hydroxyproline and growth. J. Clin. Invest. 41: 1928, 1962. CrossrefMedlineGoogle Scholar31. GROSS J: Studies on the formation of collagen. II. The influence of growth rate on neutral salt extracts of guinea pig dermis. J. Exp. Med. 107: 265, 1958. CrossrefMedlineGoogle Scholar32. KEISERSJOERDSMA HRA: Effect of thyroid hormone on collagen metabolism (abstract). J. Clin. Invest. 41: 1371, 1962. Google Scholar33. KEISERGILLSJOERDSMABARTTER HRJRAFC: Relation between urinary hydroxyproline and parathyroid function. J. Clin. Invest. 43: 1073, 1964. CrossrefMedlineGoogle Scholar34. NEUMANLOGAN REMA: The determination of hydroxyproline. J. Biol. Chem. 184: 299, 1950. CrossrefMedlineGoogle Scholar35. PROCKOPUDENFRIEND DJS: A specific method for the analysis of hydroxyproline in tissues and urine. Anal. Biochem. 1: 228, 1960. CrossrefMedlineGoogle Scholar36. KEISERLEROYUDENFRIENDSJOERDSMA HECSA: Collagen-like protein in human plasma. Science 142: 1678, 1963. CrossrefMedlineGoogle Scholar37. LEROYKAPLANUDENFRIENDSJOERDSMA ECASA: A hydroxyproline-containing, collagen-like protein in plasma and a procedure for its assay. J. Biol. Chem. 239: 3350, 1964. CrossrefMedlineGoogle Scholar38. WALKERLAPIEREGROSS DGCMJ: A collagenolytic factor in rat bone promoted by parathyroid extract. Biochem. Biophys. Res. Commun. 15: 397, 1964. CrossrefMedlineGoogle Scholar39. GOLDSTEINPATELHOUCK ERYMJC: Collagenolytic activity of intact and necrotic connective tissue. Science 146: 942, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Heart Institute, National Institutes of Health, Public Health Service, United States Department of Health, Education, and Welfare.Requests for reprints should be addressed to Albert Sjoerdsma, M.D., Chief, Experimental Therapeutics Branch, National Heart Institute, Bldg. 10, Room 7-N-260, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUrinary Hydroxyproline Is Only Suitable As a Biomarker for Acute Intake, Up to 6 hr Postingestion of Collagen Proteins in “Free-Living,” Healthy, Active MalesEffects of Recombinant Human Lactoferrin on Osteoblast Growth and Bone Status in PigletsBiochemistry of the HydroxyprolinesCoagulopathy during ascites reinfusion: Prevention by antiplatelet therapySodium-Calcium Inter-Relationships with Specific Reference to OsteoporosisBone resorption and hypercalciuria in calcium stoneformersThe Postabsorptive Hydroxyproline in the Long-Term Evaluation of Patients With Breast CancerThe Connective Tissue in SclerodermaTuberous sclerosis: Hydroxyproline content in urine and tissuesChanges in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescentsDisordered mineral metabolism produced by ketogenic diet therapyBone remodeling and calcium metabolism: A correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's diseaseTotal hydroxyproline in urine of 4 to 6 year-old children?an investigation on its relationship to growth and nutritionSerum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin DSerum Free Proline and Free Hydroxyproline in Patients with Chronic Liver DiseaseUrinary Hydroxyproline in Pregnancy — An Index of Placental Function A Preliminary ReportHydroxyproline Concentrations in Ligaments From Trained and Nontrained RatsZum verhalten der kollagenpeptidase im serum bei verschiedenen HautkrankheitenCollagen: Its structure and function in normal and pathological connective tissuesA prolidase deficiency in man with iminopeptiduriaCOLLAGEN-LIKE PROTEIN IN SERUM OF PATIENTS WITH CONNECTIVE TISSUE DISORDERSTotal urinary hydroxyproline excreted in healing experimental rat rickets, studied with14C prolineNondialyzable peptide-bound hydroxyproline in human amniotic fluid: An indicator of fetal growthHydroxyproline content of plasma proteinsSKIN COLLAGEN AND THICKNESS IN HYPERTHYROIDISM AND MYXOEDEMAAnalyse de l'hydroxyproline urinaire. Méthode et valeurs fréquentesBone Collagen Turnover in Idiopathic Scoliosis Estimated from Total Hydroxyproline ExcretionNew directions in the chemistry of natural products: The organic chemist as a pathfinder for biochemistry and medicineThe pattern of ATP-creatine phosphotransferase activity in growing long bones of new-born micePlasma hydroxyproline-containing protein (hypro-protein)Urinary peptide hydroxyproline before and during postpartum involution of human uterusUrinary Excretion of Hydroxyproline in Health and DiseaseHereditary hyperphosphatasiaFraktionierung hydroxyprolin-haltiger harnpeptide mittels sephadex-gelfiltrationDissociation between changes in urinary total hydroxyproline and plasma alkaline phosphatase after removal of parathyroid tumourDirect measurement of the rate of collagen synthesis in skinUrinary excretion of prolylhydroxyproline in rheumatic diseases.Methodological Studies of the Distribution of Hydroxyproline in Human SerumA rapid serum screening test for increased osteoblastic activityChanges in urinary hydroxyproline in premature infantsHyperprolinemia andhyperprolinuria in thalassemiaUrinary excretion of hydroxyproline and proline during surgical stressTotal hydroxyproline excretion during prolonged starvation for obesityHydroxyproline excretion during starvation of obese subjectsTOTAL URINARY HYDROXYPROLINE EXCRETION AFTER ADMINISTRATION OF VITAMIN D TO HEALTHY VOLUNTEERS AND A PATIENT WITH OSTEOMALACIARecent Progress in Osteomalacia and RicketsA. ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.The treatment of adult phosphate diabetes and Fanconi syndrome with neutral sodium phosphateTotal urinary hydroxyproline in primary hyperparathyroidism. An assessment of its clinical significanceAlkaline PhosphataseSOLOMON POSEN, M.D., F.R.A.C.P.Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism Biochemistry and Clinical ApplicationsDARWIN J. PROCKOP, M.D., PH.D., KARI I. KIVIRIKKO, M.D.Idiopathic periostitis with hypercalcemiaCollagenolytic activity of snake and spider venomsThe Technique and Significance of Hydroxyproline Measurement in ManA modified procedure for radioactive hydroxyproline assay in urine and tissues after labeled proline administrationEFFECT OF PENICILLAMINE ON HUMAN COLLAGEN AND ITS POSSIBLE APPLICATION TO TREATMENT OF SCLERODERMACOLLAGEN PROFILE IN VARIOUS CLINICAL CONDITIONS 1 October 1965Volume 63, Issue 4Page: 672-694KeywordsBlood plasmaHeartMedical servicesPathogenesisPlasma proteinsPrevention, policy, and public healthProteinsSclerodermaTendonsThyroid Issue Published: 1 October 1965 PDF downloadLoading ...