The metabolism and metabolic effects of ketoacids
1989; Wiley; Volume: 5; Issue: 1 Linguagem: Inglês
10.1002/dmr.5610050106
ISSN1099-0895
Autores Tópico(s)Metabolism and Genetic Disorders
ResumoDiabetes/Metabolism ReviewsVolume 5, Issue 1 p. 71-82 Protein and Amino Acid Metabolism The metabolism and metabolic effects of ketoacids R. C. May, R. C. May Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322Search for more papers by this authorW. E. Mitch, W. E. Mitch Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322Search for more papers by this author R. C. May, R. C. May Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322Search for more papers by this authorW. E. Mitch, W. E. Mitch Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322Search for more papers by this author First published: February 1989 https://doi.org/10.1002/dmr.5610050106Citations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Burns S, Cresswell J, Ell S, Flynn M, Jackson MA, Lee HA, Richards P, Rowlands A, and Talbot S: Comparison of the effects of ketoacid analogues and essential amino acids on nitrogen homeostatis in moderately protein-restricted diets. 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FEBS Lett 157: 59–62, 1983. 43 Patel TB, and Olson MS: Evidence for the regulation of the branched-chain α-keto acid dehydrogenase multienzyme complex by a phosphorylation/dephosphorylation mechanism. Biochemistry 21: 4259–4264, 1982. 44 Paxton R, and Harris RA: Regulation of branched-chain α-ketoacid dehydrogenase kinase. Arch Biochem Biophys 231: 48–57, 1984. 45 Block KP, and Harper AE: Valine metabolism in vivo: Effects of high dietary levels of leucine and isoleucine. Metabolism 33: 559–566, 1984. 46 Zapalowski C, Miller RH, Dixon JL, and Harper AE: Effects of perfusate leucine concentration on the metabolism of valine by the isolated rat hindquarter. Metabolism 33: 922–927, 1984. 47 Mequid MM, Schwarz H, Matthews DE, et al.: In vivo and in vitro branched-chain amino acid interactions. In Amino Acids: Metabolism and Medical Applications. JP Grant, and VR Young, Eds. John Wright and Sons, Boston, 1983, pp 147–154. 48 May RC, Hara Y, Kelly RA, Block KP, Buse MG, and Mitch WE: Branched-chain amino acid metabolism in rat muscle: Abnormal regulation in acidosis. Am J Physiol 252: E712–E718, 1987. 49 Aftring RP, Block KP, and Buse MG: Leucine and isoleucine activate skeletal muscle branched-chain α-keto acid dehydrogenase in vivo. Am J Physiol 250: E599–E604, 1986. 50 Block KP, Aftring RP, Mehard WB, and Buse MG: Modulation of rat skeletal muscle branched-chain α-keto acid dehydrogenase in vivo: Effects of dietary protein and meal consumption. J Clin Invest 79: 1349–1358, 1987. 51 Block KP, Richmond WB, Mehard WB, and Buse MG: Glucocorticoid-mediated activation of muscle branched-chain α-ketoacid dehydrogenase in vivo. Am J Physiol 252: E396–E407, 1987. 52 Gillim SE, Paxton R, Cook GA, and Harris RA: Activity state of the branched-chain α-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats. 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Am J Clin Nutr 33: 1660–1666, 1980. 73 Waterlow JC, Garlick PJ, and Millward DJ: Protein Turnover in Mammalian Tissues and in the whole Body. North Holland, New York, 1978. 74 Schwenk WF, Beaufrere B, and Haymond MW: Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Physiol 249: E646–E650, 1985. 75 Goodship THJ, Young VR, Steinman TI, and Mitch WE: Adaptive response to low protein diets: What is the risk in chronic renal failure? Kidney Int 33: 376, 1988. 76 Shinnick FL, and Harper AE: Effects of branched-chain amino acid antagonism in the rat on tissue amino acid and ketoacid concentrations. J Nutr 107: 887–895, 1977. 77 Hara Y, May RC, Kelly RA, and Mitch WE: Acidosis, not azotemia, stimulates branched-chain amino acid catabolism in uremic rats. Kidney Int, 32: 808–814, 1987. 78 May RC, Kelly RA, and Mitch WE: Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J Clin Invest 77: 614–621, 1986. 79 May RC, Kelly RA, and Mitch WE: Mechanisms for defects in muscle protein metabolism in rats with chronic uremia: Influence of metabolic acidosis. J Clin Invest 79: 1099–1103, 1987. 80 Laouari D, Kamoun PP, Rocchiccioli F, Dodu C, Kleinknecht C, and Broyer M: Efficiency of substitution of α-ketoisocaproic acid and α-ketoisovaleric acid in the diet of normal and uremic growing rats. Am J Clin Nutr 44: 832–846, 1986. Citing Literature Volume5, Issue1February 1989Pages 71-82 ReferencesRelatedInformation
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