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Size‐Controlled and Biocompatible Gd 2 O 3 Nanoparticles for Dual Photoacoustic and MR Imaging

2012; Wiley; Volume: 1; Issue: 5 Linguagem: Inglês

10.1002/adhm.201200103

2192-2659

Yu Kimura, Ryota Kamisugi, Michiko Narazaki, Tetsuya Matsuda, Yasuhiko Tabata, Akio Toshimitsu, Teruyuki Kondo,

Ultrasound and Hyperthermia Applications

The synthesis, characterization, and functional evaluation of new size-controlled and biocompatible Gd2O3 nanoparticles as a bimodal contrast agent for use in photoacoustic (PA) and magnetic resonance (MR) imaging are reported. These nanoparticles show a clear PA image by themselves, without conjugation with gold, rare earth metals, or dyes. Relaxivity measurement by MR imaging clearly shows that their relaxivity, r1, is twice that of clinically available Gd-DTPA.