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Bioavailability and pharmacokinetics of a novel cephalexin oral paste formulation in fed and fasted dogs

2009; Wiley; Volume: 32; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2885.2008.01047.x

1365-2885

Alan Chicoine, William R Cox, Lingli Huang, Guo-Juan Wang, Patricia M. Dowling,

Analytical Methods in Pharmaceuticals

Journal of Veterinary Pharmacology and TherapeuticsVolume 32, Issue 4 p. 400-402 Bioavailability and pharmacokinetics of a novel cephalexin oral paste formulation in fed and fasted dogs A. CHICOINE, A. CHICOINE Department of Veterinary Biomedical Sciences, Western College of Veterinary MedicineSearch for more papers by this authorW. COX, W. COX Canadian Animal Health Management Services, Chilliwack, BC, CanadaSearch for more papers by this authorL. HUANG, L. HUANG JR Laboratories, Burnaby, BC, CanadaSearch for more papers by this authorG. WANG, G. WANG JR Laboratories, Burnaby, BC, CanadaSearch for more papers by this authorP. DOWLING, P. DOWLING Department of Veterinary Biomedical Sciences, Western College of Veterinary MedicineSearch for more papers by this author A. CHICOINE, A. CHICOINE Department of Veterinary Biomedical Sciences, Western College of Veterinary MedicineSearch for more papers by this authorW. COX, W. COX Canadian Animal Health Management Services, Chilliwack, BC, CanadaSearch for more papers by this authorL. HUANG, L. HUANG JR Laboratories, Burnaby, BC, CanadaSearch for more papers by this authorG. WANG, G. WANG JR Laboratories, Burnaby, BC, CanadaSearch for more papers by this authorP. DOWLING, P. DOWLING Department of Veterinary Biomedical Sciences, Western College of Veterinary MedicineSearch for more papers by this author First published: 08 July 2009 https://doi.org/10.1111/j.1365-2885.2008.01047.xCitations: 2 Alan Chicoine, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Berlioz, F., Lepére-Prevot, B., Julien, S., Tsocas, A., Carbon, C., Rozé, C. & Farinotti, R. (2000) Chronic nifedipine dosing enhances cephalexin bioavailability and intestinal absorption in conscious rats. Drug Metabolism and Disposition, 28, 1267–1269. Campbell, B.G. & Rosin, E. (1998) Effect of food on absorption of cefadroxil and cephalexin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 21, 418–420. Carli, S., Anfossi, P., Villa, R., Castellani, G., Mengozzi, G. & Montesissa, C. (1999) Absorption kinetics and bioavailability of cephalexin in the dog after oral and itnramuscular administration. Journal of Veterinary Pharmacology and Therapeutics, 22, 308–313. Craig, W.A. (1995) Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagnostic Microbiology and Infectious Disease, 22, 89–96. Crosse, R. & Burt, D.G. (1984) Antibiotic concentration in the serum of dogs and cats following a single oral dose of cephalexin. The Veterinary Record, 115, 106–107. Davis, J.L., Salmon, J.H. & Papich, M.G. (2005) Pharmacokinetics and tissue fluid distribution of cephalexin in the horse after oral and i.v. administration. Journal of Veterinary Pharmacology and Therapeutics, 28, 425–431. Frank, L.A. & Kunkle, G.A. (1993) Comparison of the efficacy of cefadroxil and generic and proprietary cephalexin in the treatment of pyoderma in dogs. Journal of the American Veterinary Medical Association, 203, 530–533. Frimodt-Moller, N., Bentzon, M.W. & Thomson, V.F. (1986) Experimental infection with Streptococcus pneumoniae in mice: correlation of in vitro and pharmacokinetic parameters with in vivo effect for 14 cephalosporins. Journal of Infectious Diseases, 154, 511–517. Ganiere, J.P., Medaille, C. & Mangion, C. (2005) Antimicrobial drug susceptibility of Staphyloccocus intermedius clinical isolates from canine pyoderma. Journal of Veterinary Medicine, 52, 25–31. Mason, I.S. & Kietzmann, M. (1999) Cephalosporins-pharmacological basis of clinical use in veterinary dermatology. Veterinary Dermatology, 10, 187–192. Prados, A.P., Vreil, V., Albarellos, G., Waxman, S. & Rebuelto, M. (2007a) Metoclopramide modifies oral cephalexin pharmacokinetics in dogs. Journal of Veterinary Pharmacology and Therapeutics, 30, 127–131. Prados, A.P., Ambrose, L., Montoya, L. & Rebuelto, M. (2007b) Chronopharmacological study of cephalexin in dogs. Chronobiology International, 24, 161–170. Prescott, J.F. (2006) Beta-lactam antibiotics: cephalosporins. In Antimicrobial Therapy in Veterinary Medicine, 4th edn. Eds S. Giguere, J.F. Prescott, J.D. Baggot, R.D. Walker & P.M. Dowling, pp. 139–148. Blackwell Publishing, Ames, Iowa. Rebuelto, M., Montoya, L., Kreil, V., Ambros, L., Waxman, S., Albarellos, G. & Hallu, R. (2005) Pharmacokinetics of two once-daily parenteral cephalexin formulations in dogs. Journal of Veterinary Pharmacology and Therapeutics, 28, 419–423. Sasaki, T., Kikuchi, K., Tanaka, Y., Takahashi, N., Kamata, S. & Hiramatsu, K. (2007) Reclassification of phenotypically identified Staphylococcus intermedius stains. Journal of Clinical Microbiology, 45, 2770–2778. Scott, D., Miller, W. & Griffin, C. (2001) Muller & Kirk's Small Animal Dermatology, 6th edn. W.B. Saunders, Toronto. Shimizu, A., Wakita, Y., Nagase, S., Okabe, M., Koji, T., Hayashi, T., Nagase, N., Sasaki, A., Kawano, J., Yamashita, K. & Takagi, M. (2001) Antimicrobial susceptibility of Staphylococcus intermedius isolated from healthy and diseased dogs. Journal of Veterinary Medical Science, 63, 357–360. Silley, P., Rudd, A.P., Symington, W.M. & Tait, A.J. (1988) Pharmacokinetics of cephalexin in dogs and cats after oral, subcutaneous and intramuscular administration. The Veterinary Record, 122, 15–17. Wackowiez, G., Richard, J.J. & Fabreguettes, G. (1997) Pharmacokinetics of cefalexin in plasma and urine after single intravenous and oral (tablets) administration in dogs. Journal of Veterinary Pharmacology and Therapeutics, 20, 29. Citing Literature Volume32, Issue4August 2009Pages 400-402 ReferencesRelatedInformation