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The Insulin Requirement of Man after Total Pancreatectomy

1944; Oxford University Press; Volume: 4; Issue: 5 Linguagem: Inglês

10.1210/jcem-4-5-194

1945-7197

Martin G. Goldner, Dwight E. Clark,

Pancreatic and Hepatic Oncology Research

THE INSULIN requirement of a man after total pancreatectomy, always a matter of physiological interest, has become a problem of clinical importance with the development of modern pancreatic surgery (1, 2). So far, only theoretical calculations could be made as to the amount of insulin necessary to maintain, in the absence of the pancreas, normal carbohydrate metabolism in man. They were based mainly on experiences with depancreatized animals and their results vary over a wide range. Root (3) estimated that a man of 70 kg. weight would require 200 to 300 units of insulin daily; others (4) arrived at somewhat lower values (70 to 100 units per day). Holm (5) calculated that a starving man would need not more than 10 units per day and that 50 units per day would be sufficient when this man's basal caloric requirement was covered by carbodydrates exclusively. His conclusions were drawn from animal experiments with constant infusions of insulin and glucose.