β-Turn mimetic library synthesis: scaffolds and applications
2001; Elsevier BV; Volume: 57; Issue: 35 Linguagem: Inglês
10.1016/s0040-4020(01)00680-9
ISSN1464-5416
AutoresAndrew J. Souers, Jonathan A. Ellman,
Tópico(s)Click Chemistry and Applications
ResumoOver the past five years, multiple reports of parallel synthesis methodologies for β-turn mimetic libraries have been disclosed, several libraries have been produced, and biologically active turn mimetics have been identified to several different targets. This review provides a synopsis of the current state of the art of combinatorial turn mimetic synthesis and scaffold design, in addition to the applications of these technologies to biological targets.
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