Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?
2012; Wiley; Volume: 27; Issue: 9 Linguagem: Inglês
10.1002/mds.25063
ISSN1531-8257
AutoresJoana Guimarães, Eduardo Moura, Maria Augusta Vieira‐Coelho, Carolina Garrett,
Tópico(s)Transcranial Magnetic Stimulation Studies
ResumoAbstract Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus. © 2012 Movement Disorder Society
Referência(s)